Brain Tumor
Study of Sonodynamic Therapy in Participants With Recurrent High-Grade Glioma
A Phase 0 single center, first in human, open-label study of ascending energy doses of sonodynamic therapy (SDT) utilizing the MRgFUS combined with intravenous ALA to assess safety and...
Ribociclib (LEE011) in Preoperative Glioma and Meningioma Patients
In the proposed trial, patients will be administered ribociclib prior to surgical resection of their tumor. Patients will be enrolled in time-intervals sequentially (non-randomized). All patients will be...
Ribociclib and Everolimus for Glioblastoma Multiforme
In the proposed trial, patients will be administered ribociclib+everolimus prior to surgical resection of their tumor. Recurrent GBM patients will be randomized into one of the three time-interval...
The Barrow 5-ALA Intraoperative Confocal (BALANCE) Study
This study will look at how well 5-ALA, an amino acid compound, can identify cancer cells during surgery and improve tumor removal in patients with high- and low-grade...