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    Publications: Department of Neurobiology

    Bakkar N, Kovalik T, Lorenzini I, Spangler S, Lacoste A, Sponaugle K, Ferrante P, Argentinis E, Sattler R, Bowser R.
    Artificial intelligence in neurodegenerative disease research: use of IBM Watson to identify additional RNA-binding proteins altered in amyotrophic lateral sclerosis.
    Acta Neuropathol. 2018 Feb;135(2):227-247.
    doi: 10.1007/s00401-017-1785-8. Epub 2017 Nov 13.
    PubMed PMID: 29134320; PubMed Central PMCID: PMC5773659.

    Boehringer A, Garcia-Mansfield K, Singh G, Bakkar N, Pirrotte P, Bowser R.
    ALS associated mutations in Matrin 3 alter protein-protein interactions and impede mRNA nuclear export.
    Sci Rep. 2017 Nov 6;7(1):14529.
    doi: 10.1038/s41598-017-14924-6.
    PubMed PMID: 29109432; PubMed Central PMCID: PMC5674072.

    Chu KMI, Seto SH, Beloozerova IN, Marlinski V.
    Strategies for obstacle avoidance during walking in the cat.
    J Neurophysiol. 2017 Aug 1;118(2):817-831.
    doi: 10.1152/jn.00033.2017. Epub 2017 Mar 29.
    PubMed PMID: 28356468; PubMed Central PMCID: PMC5539443.

    Coyne AN, Lorenzini I, Chou CC, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz JC, Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC.
    Post-transcriptional inhibition of Hsc70-4/HSPA8 expression leads to synaptic vesicle cycling defects in multiple models of ALS.
    Cell Rep. 2017 Oct 3;21(1):110-125.
    doi: 10.1016/j.celrep.2017.09.028.
    PubMed PMID: 28978466; PubMed Central PMCID: PMC5679478.

    Edler MK, Sherwood CC, Meindl RS, Hopkins WD, Ely JJ, Erwin JM, Mufson EJ, Hof PR, Raghanti MA.
    Aged chimpanzees exhibit pathologic hallmarks of Alzheimer’s disease.
    Neurobiol Aging. 2017 Nov;59:107-120.
    doi: 10.1016/j.neurobiolaging.2017.07.006. Epub 2017 Aug 1.
    PubMed PMID: 28888720.

    Eschbacher JM, Georges JF, Belykh E, Yazdanabadi MI, Martirosyan NL, Szeto E, Seiler CY, Mooney MA, Daniels JK, Goehring KY, Van Keuren-Jensen KR, Preul MC, Coons SW, Mehta S, Nakaji P.
    Immediate label-free ex vivo evaluation of human brain tumor biopsies with confocal reflectance microscopy.
    J Neuropathol Exp Neurol. 2017 Dec 1;76(12):1008-1022.
    doi: 10.1093/jnen/nlx089.
    PubMed PMID: 29136454.

    Feng Y, Liao S, Wei C, Jia D, Wood K, Liu Q, Wang X, Shi FD, Jin WN.
    Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models.
    J Neuroinflammation. 2017 Dec 15;14(1):248.
    doi: 10.1186/s12974-017-1017-0.
    PubMed PMID: 29246244; PubMed Central PMCID: PMC5732427.

    Ferguson SA, Mouzon BC, Lynch C, Lungmus C, Morin A, Crynen G, Carper B, Bieler G, Mufson EJ, Stewart W, Mullan M, Crawford F.
    Negative impact of female sex on outcomes from repetitive mild traumatic brain injury in hTau mice is age dependent: a chronic effects of neurotrauma consortium study.
    Front Aging Neurosci. 2017 Dec 22;9:416.
    doi: 10.3389/fnagi.2017.00416. eCollection 2017.
    PubMed PMID: 29311903; PubMed Central PMCID: PMC5744460.

    Finch NA, Wang X, Baker MC, Heckman MG, Gendron TF, Bieniek KF, Wuu J, DeJesus-Hernandez M, Brown PH, Chew J, Jansen-West KR, Daughrity LM, Nicholson AM, Murray ME, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Petrucelli L, Boeve BF, Graff-Radford NR, Asmann YW, Dickson DW, Benatar M, Bowser R, Boylan KB, Rademakers R, van Blitterswijk M.
    Abnormal expression of homeobox genes and transthyretin in C9ORF72 expansion carriers.
    Neurol Genet. 2017 Jun 7;3(4):e161.
    doi: 10.1212/NXG.0000000000000161. eCollection 2017 Aug.
    PubMed PMID: 28660252; PubMed Central PMCID: PMC5479438.

    Garami A, Ibrahim M, Gilbraith K, Khanna R, Pakai E, Miko A, Pinter E, Romanovsky AA, Porreca F, Patwardhan AM.
    Transient receptor potential vanilloid 1 antagonists prevent anesthesia-induced hypothermia and decrease postincisional opioid dose requirements in rodents.
    Anesthesiology. 2017 Nov;127(5):813-823.
    doi: 10.1097/ALN.0000000000001812.
    PubMed PMID: 28806222.

    Ginsberg SD, Malek-Ahmadi MH, Alldred MJ, Che S, Elarova I, Chen Y, Jeanneteau F, Kranz TM, Chao MV, Counts SE, Mufson EJ.
    Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer’s disease.
    Hippocampus. 2017 Sep 9.
    doi: 10.1002/hipo.22802. [Epub ahead of print]
    PubMed PMID: 28888073.

    Heffernan JM, McNamara JB, Borwege S, Vernon BL, Sanai N, Mehta S, Sirianni RW.
    PNIPAAm-co-Jeffamine(®) (PNJ) scaffolds as in vitro models for niche enrichment of glioblastoma stem-like cells.
    Biomaterials. 2017 Oct;143:149-158.
    doi: 10.1016/j.biomaterials.2017.05.007. Epub 2017 May 6.
    PubMed PMID: 28802102; PubMed Central PMCID: PMC5605153.

    Huh S, Siripuram R, Lee RH, Turkin VV, O’Neill D, Hamm TM, Heckman CJ, Manuel M.
    PICs in motoneurons do not scale with the size of the animal: a possible mechanism for faster speed of muscle contraction in smaller species.
    J Neurophysiol. 2017 Jul 1;118(1):93-102.
    doi: 10.1152/jn.00045.2017. Epub 2017 Mar 29.
    PubMed PMID: 28356469; PubMed Central PMCID: PMC5494365.

    Jiang W, Li D, Han R, Zhang C, Jin WN, Wood K, Liu Q, Shi FD, Hao J.
    Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages.
    Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6202-E6211.
    doi: 10.1073/pnas.1705491114. Epub 2017 Jul 10.
    PubMed PMID: 28696300; PubMed Central PMCID: PMC5544318.

    Kosty J, Lu F, Kupp R, Mehta S, Lu QR.
    Harnessing OLIG2 function in tumorigenicity and plasticity to target malignant gliomas.
    Cell Cycle. 2017 Sep 17;16(18):1654-1660.
    doi: 10.1080/15384101.2017.1361062. Epub 2017 Aug 14.
    PubMed PMID: 28806136; PubMed Central PMCID: PMC5602295.

    Li HD, Li M, Shi E, Jin WN, Wood K, Gonzales R, Liu Q.
    A translocator protein 18 kDa agonist protects against cerebral ischemia/reperfusion injury.
    J Neuroinflammation. 2017 Jul 28;14(1):151.
    doi: 10.1186/s12974-017-0921-7.
    PubMed PMID: 28754131; PubMed Central PMCID: PMC5534039.

    Li LM, Zhang C, Zhang LJ, Guo HY, Yang CS, Zhang R, Li YJ, Shi FD, Yang L.
    Relapse of neuromyelitis optica associated with oral progestin.
    J Neurol Neurosurg Psychiatry. 2017 Oct 9.
    pii: jnnp-2017-316356. doi: 10.1136/jnnp-2017-316356. [Epub ahead of print]
    PubMed PMID: 28993474.

    Li M, Li Z, Ren H, Jin WN, Wood K, Liu Q, Sheth KN, Shi FD.
    Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage.
    J Cereb Blood Flow Metab. 2017 Jul;37(7):2383-2395.
    doi: 10.1177/0271678X16666551. Epub 2016 Jan 1.
    PubMed PMID: 27596835; PubMed Central PMCID: PMC5482387.

    Li M, Ren H, Sheth KN, Shi FD, Liu Q.
    A TSPO ligand attenuates brain injury after intracerebral hemorrhage.
    FASEB J. 2017 Aug;31(8):3278-3287.
    doi: 10.1096/fj.201601377RR. Epub 2017 Apr 17.
    PubMed PMID: 28416580; PubMed Central PMCID: PMC5503714.

    Li T, Zhang LJ, Zhang QX, Yang CS, Zhang C, Li YJ, Shi FD, Yang L.
    Anti-Rituximab antibody in patients with NMOSDs treated with low dose Rituximab.
    J Neuroimmunol. 2017 Dec 28.
    pii: S0165-5728(17)30407-1. doi: 10.1016/j.jneuroim.2017.12.021. [Epub ahead of print]
    PubMed PMID: 29310942.

    Li Z, Li M, Wood K, Hettwer S, Muley SA, Shi FD, Liu Q, Ladha SS.
    Engineered agrin attenuates the severity of experimental autoimmune myasthenia gravis.
    Muscle Nerve. 2017 Nov 28.
    doi: 10.1002/mus.26025. [Epub ahead of print]
    PubMed PMID: 29193204.

    Liu Q, Whiteaker P, Morley BJ, Shi FD, Lukas RJ.
    Distinctive roles for α7*-and α9*-nicotinic acetylcholine receptors in inflammatory and autoimmune responses in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis.
    Front Cell Neurosci. 2017 Sep 22;11:287.
    doi: 10.3389/fncel.2017.00287. eCollection 2017.
    PubMed PMID: 29018331; PubMed Central PMCID: PMC5615207.

    Liu XW, Yang Y, Wang W, Wang S, Gao M, Wu J, Tao N.
    Plasmonic-based electrochemical impedance imaging of electrical activities in single cells.
    Angew Chem Int Ed Engl. 2017 Jul 17;56(30):8855-8859.
    doi: 10.1002/anie.201703033. Epub 2017 May 15.
    PubMed PMID: 28504338.

    Liu Y, Jiang X, Butzkueven H, Duan Y, Huang J, Ren Z, Dong H, Shi FD, Barkhof F, Li K, Wang J.
    Multimodal characterization of gray matter alterations in neuromyelitis optica.
    Mult Scler. 2017 Jul 1:1352458517721053.
    doi: 10.1177/1352458517721053. [Epub ahead of print]
    PubMed PMID: 28741987.

    Mehta S, Lo Cascio C.
    Developmentally regulated signaling pathways in glioma invasion.
    Cell Mol Life Sci. 2018 Feb;75(3):385-402.
    doi: 10.1007/s00018-017-2608-8. Epub 2017 Aug 18. Review.
    PubMed PMID: 28821904; PubMed Central PMCID: PMC5765207.

    Meyer CW, Ootsuka Y, Romanovsky AA.
    Body temperature measurements for metabolic phenotyping in mice.
    Front Physiol. 2017 Jul 31;8:520.
    doi: 10.3389/fphys.2017.00520. eCollection 2017.
    PubMed PMID: 28824441; PubMed Central PMCID: PMC5534453.

    Mi Z, Abrahamson EE, Ryu AY, Fish KN, Sweet RA, Mufson EJ, Ikonomovic MD.
    Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer’s disease.
    Neurobiol Aging. 2017 Jul;55:159-166.
    doi: 10.1016/j.neurobiolaging.2017.01.022. Epub 2017 Feb 4.
    PubMed PMID: 28259365; PubMed Central PMCID: PMC5440205.

    Perez SE, Nadeem M, Malek-Ahmadi MH, He B, Mufson EJ.
    Frontal cortex and hippocampal γ-secretase activating protein levels in prodromal Alzheimer disease.
    Neurodegener Dis. 2017;17(6):235-241.
    doi: 10.1159/000477937. Epub 2017 Jul 26.
    PubMed PMID: 28743126; PubMed Central PMCID: PMC5730491.

    Prakapenka AV, Bimonte-Nelson HA, Sirianni RW.
    Engineering poly(lactic-co-glycolic acid) (PLGA) micro- and nano-carriers for controlled delivery of 17β-Estradiol.
    Ann Biomed Eng. 2017 Jul;45(7):1697-1709.
    doi: 10.1007/s10439-017-1859-8. Epub 2017 Jun 20.
    PubMed PMID: 28634732; PubMed Central PMCID: PMC5599155.

    Prakapenka AV, Hiroi R, Quihuis AM, Carson C, Patel S, Berns-Leone C, Fox C, Sirianni RW, Bimonte-Nelson HA.
    Contrasting effects of individual versus combined estrogen and progestogen regimens as working memory load increases in middle-aged ovariectomized rats: one plus one does not equal two.
    Neurobiol Aging. 2017 Dec 7;64:1-14.
    doi: 10.1016/j.neurobiolaging.2017.11.015. [Epub ahead of print]
    PubMed PMID: 29316527.

    Ren H, Kong Y, Liu Z, Zang D, Yang X, Wood K, Li M, Liu Q.
    Selective NLRP3 (Pyrin Domain-Containing Protein 3) inflammasome inhibitor reduces brain injury  after intracerebral hemorrhage.
    Stroke. 2018 Jan;49(1):184-192.
    doi: 10.1161/STROKEAHA.117.018904. Epub 2017 Dec 6.
    PubMed PMID: 29212744; PubMed Central PMCID: PMC5753818.

    Sreekrishnan A, Leasure AC, Shi FD, Hwang DY, Schindler JL, Petersen NH, Gilmore EJ, Kamel H, Sansing LH, Greer DM, Sheth KN.
    Functional improvement among intracerebral hemorrhage (ICH) survivors up to 12 months post-injury.
    Neurocrit Care. 2017 Dec;27(3):326-333.
    doi: 10.1007/s12028-017-0425-4.
    PubMed PMID: 28685394; PubMed Central PMCID: PMC5700855.

    Steffensen SC, Shin SI, Nelson AC, Pistorius SS, Williams SB, Woodward TJ, Park HJ, Friend L, Gao M, Gao F, Taylor DH, Foster Olive M, Edwards JG, Sudweeks SN, Buhlman LM, Michael McIntosh J, Wu J.
    α6 subunit-containing nicotinic receptors mediate low-dose ethanol effects on ventral tegmental area neurons and ethanol reward.
    Addict Biol. 2017 Sep 13.
    doi: 10.1111/adb.12559. [Epub ahead of print]
    PubMed PMID: 28901722.

    Sun GZ, He YC, Ma XK, Li ST, Chen DJ, Gao M, Qiu SF, Yin JX, Shi J, Wu J.
    Hippocampal synaptic and neural network deficits in young mice carrying the human APOE4 gene.
    CNS Neurosci Ther. 2017 Sep;23(9):748-758.
    doi: 10.1111/cns.12720. Epub 2017 Aug 7.
    PubMed PMID: 28786172.

    Tian DC, Su L, Fan M, Yang J, Zhang R, Wen P, Han Y, Yu C, Zhang C, Ren H, Shi K, Zhu Z, Dong Y, Liu Y, Shi FD.
    Bidirectional degeneration in the visual pathway in neuromyelitis optica spectrum disorder (NMOSD).
    Mult Scler. 2017 Aug 1:1352458517727604.
    doi: 10.1177/1352458517727604. [Epub ahead of print]
    PubMed PMID: 28823217.

    Wang Z, Guo W, Liu Y, Gong Y, Ding X, Shi K, Thome R, Zhang GX, Shi FD, Yan Y.
    Low expression of complement inhibitory protein CD59 contributes to humoral autoimmunity against astrocytes.
    Brain Behav Immun. 2017 Oct;65:173-182.
    doi: 10.1016/j.bbi.2017.04.023. Epub 2017 May 2.
    PubMed PMID: 28476558.

    Wanner SP, Almeida MC, Shimansky YP, Oliveira DL, Eales JR, Coimbra CC, Romanovsky AA.
    Cold-induced thermogenesis and inflammation-associated cold-seeking behavior are represented by different dorsomedial hypothalamic sites: a three-dimensional functional topography study in conscious rats.
    J Neurosci. 2017 Jul 19;37(29):6956-6971.
    doi: 10.1523/JNEUROSCI.0100-17.2017. Epub 2017 Jun 19.
    PubMed PMID: 28630253; PubMed Central PMCID: PMC5518423.

    Xia K, Ma Z, Shen J, Li M, Hou B, Gao M, Zhang S, Wu J.
    The 2-aminoethoxydiphenyl borate analog, DPB161 blocks store-operated Ca(2+) entry in acutely dissociated rat submandibular cells.
    Oncotarget. 2017 Jun 27;8(37):61551-61560.
    doi: 10.18632/oncotarget.18623. eCollection 2017 Sep 22.
    PubMed PMID: 28977884; PubMed Central PMCID: PMC5617444.

    Zhang C, Tian DC, Yang CS, Han B, Wang J, Yang L, Shi FD.
    Safety and efficacy of bortezomib in patients with highly relapsing neuromyelitis optica spectrum disorder.
    JAMA Neurol. 2017 Aug 1;74(8):1010-1012.
    doi: 10.1001/jamaneurol.2017.1336.
    PubMed PMID: 28692708.

    Zhang F, Yan C, Wei C, Yao Y, Ma X, Gong Z, Liu S, Zang D, Chen J, Shi FD, Hao J.
    Vinpocetine inhibits NF-κB-dependent inflammation in acute ischemic stroke patients.
    Transl Stroke Res. 2017 Jul 9.
    doi: 10.1007/s12975-017-0549-z. [Epub ahead of print]
    PubMed PMID: 28691141.

    Zhang J, Shi K, Li Z, Li M, Han Y, Wang L, Zhang Z, Yu C, Zhang F, Song L, Dong JF, La Cava A, Sheth KN, Shi FD.
    Organ- and cell-specific immune responses are associated with the outcomes of intracerebral hemorrhage.
    FASEB J. 2018 Jan;32(1):220-229.
    doi: 10.1096/fj.201700324R. Epub 2017 Sep 6.
    PubMed PMID: 28877956; PubMed Central PMCID: PMC5731128.

    Zhang S, Zhou Y, Zhang R, Zhang M, Campbell B, Lin L, Shi FD, Lou M.
    Rationale and design of combination of an immune modulator fingolimod with alteplase bridging with mechanical thrombectomy in acute ischemic stroke (FAMTAIS) trial.
    Int J Stroke. 2017 Oct;12(8):906-909.
    doi: 10.1177/1747493017710340. Epub 2017 Jun 1.
    PubMed PMID: 28569122.

    Zhang Y, Han B, He Y, Li D, Ma X, Liu Q, Hao J.
    MicroRNA-132 attenuates neurobehavioral and neuropathological changes associated with intracerebral hemorrhage in mice.
    Neurochem Int. 2017 Jul;107:182-190.
    doi: 10.1016/j.neuint.2016.11.011. Epub 2016 Dec 9.
    PubMed PMID: 27940326.

    Zhou Y, Cai W, Zhao Z, Hilton T, Wang M, Yeon J, Liu W, Zhang F, Shi FD, Wu X, Thiagarajan P, Li M, Zhang J, Dong JF.
    Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice.
    Blood. 2017 Nov 21.
    pii: blood-2017-08-801738. doi: 10.1182/blood-2017-08-801738. [Epub ahead of print]
    PubMed PMID: 29162596.

    About Barrow

    Since our doors opened as a regional specialty center in 1962, we have grown into one of the premier destinations in the world for neurology and neurosurgery. Our experienced, highly skilled, and comprehensive team of neurological specialists can provide you with a complete spectrum of care–from diagnosis through outpatient neurorehabilitation–under one roof. Barrow Neurological Institute: Discover. Educate. Heal.