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  • portrait of Dr. An-Chi Tien

    Contact Dr. Tien

    Call (602) 406-4493 or email [email protected]

    Specialties

    An-Chi Tien, PhD

    Assistant Professor,
    Neurobiology (602) 406-4493

    An-Chi Tien, PhD, is an assistant professor in the Department of Neurobiology at Barrow Neurological Institute. He works in the Ivy Brain Tumor Center.

    Dr. Tien’s expertise includes developmental biology and genetics, particularly applied to neuro-oncology. Dr. Tien is a member of the American Brain Tumor Association Alumni Research Network, the American Society of Clinical Oncology, and the Society for Neuro-Oncology.

    Dr. Tien earned his doctorate degree in developmental biology from the Baylor College of Medicine in Houston. He completed his postdoctoral research fellowship at University of California San Francisco’s Institute for Regenerative Medicine.

    Dr. Tien’s research focuses on establishing and optimizing pharmacodynamic tests to support clinical trials for patients with brain tumors and to better understand tumor resistance mechanisms.

    Education & Training
    • Postdoctoral Research Fellowship, University of California San Francisco, Institute for Regenerative Medicine, 2009-2016
    • PhD, Baylor College of Medicine, Developmental Biology, 2009
    • BS, National Taiwan University, Zoology, 2002
    Professional Memberships
    • American Brain Tumor Association Alumni Research Network
    • American Society of Clinical Oncology
    • Society for Neuro-Oncology
    Honors and Awards
    • Postdoctoral Fellowship, American Brain Tumor Association, 2012-2014
    • Travel Award, Keystone Symposia on Molecular and Cellular Biology, Development and Cancer, 2008
    Selected Publications
    1. Tien AC, Li J, Bao X, Derogatis A, Kim S, Mehta S, Sanai N. A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort. Clin Cancer Res. 2019;25(19):5777-5786.
    2. Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR6 Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham MC, Persson AI, Weiss WA, Batchelor TT, Stemmer-Rachamimov A, Suvà ML, Phillips JJ, Aghi MK, Mehta S, Jain RK, Rowitch DH. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. 2018;33(5):874-889.
    3. Zhou J, Tien AC, Alberta JA, Ficarro SB, Griveau A, Sun Y, Deshpande JS, Card JD, Morgan-Smith M, Michowski W, Hashizume R, James CD, Ligon KL, Snider WD, Sicinski P, Marto JA, Rowitch DH, Stiles CD. A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2. Cell Rep. 2018;18(13):3167-3177.
    4. Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP. Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science. 2016;351(6271):379-84.
    5. Kupp R, Shtayer L, Tien AC, Szeto E, Sanai N, Rotwich DH, Mehta S. Lineage-Restricted OLIG2-RTK Signaling Governs the Molecular Subtype of Glioma Stem-like Cells. Cell Rep. 2016;16(11):2838-2845.
    6. Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY. Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron. 2012;75(3):425-36.
    7. Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY, Jan YN, Jan LY. Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med (Berl). 2012;90(5):575-85.
    8. Tien AC, Tsai HH, Molofsky AV, McMahon M, Foo LC, Kaul A, Doughtery JD, Heintz N, Gutmann DH, Barres BA, Rowitch DH. Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development. 2012;139(14):2477-87.
    9. Tong C, Ohyama T, Tien AC, Rajan A, Haueter CM, Bellen HJ. Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in Drosophila visual system via Rab6. Neuron. 2011;71(3):447-59.
    10. Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien AC, Fu H, Petryniak MA, Potter GB, Liu Z, Powers JF, Runquist IS, Rowitch DH, Stiles CD. Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron. 2011;69(5):906-17.

    About Barrow Neurological Institute

    Since our doors opened as a regional specialty center in 1962, we have grown into one of the premier destinations in the world for neurology and neurosurgery. Our experienced, highly skilled, and comprehensive team of neurological specialists can provide you with a complete spectrum of care–from diagnosis through outpatient neurorehabilitation–under one roof. Barrow Neurological Institute: Discover. Educate. Heal.