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  • Fredric Manfredsson, PhD

    Associate Professor, Neurobiology

    Fredric Manfredsson, PhD, is an associate professor in the Department of Neurobiology at Barrow Neurological Institute.

    Dr. Manfredsson’s expertise includes microbiology and virology, with a special interest in gene therapy for Parkinson disease and other neurodegenerative diseases. He is a member of the American Society for Gene & Cell Therapy, The American Society for Neural Therapy and Repair, and the Society for Neuroscience.

    Dr. Manfredsson earned his doctorate degree in neuroscience from the University of Florida in Gainesville, where he also completed a postdoctoral fellowship in neuroscience.

    Dr. Manfredsson’s research has multiple focuses. One aspect is to better understand the role of the protein alpha-synuclein in both healthy cells and those affected by Parkinson’s disease. His research also emphasizes understanding the symptomology of the disease, with a focus on the treatment of levodopa-induced dyskinesia and nonmotor symptoms experienced by nearly all patients with Parkinson’s disease.

    Education & Training
    • Postdoctoral Fellowship, University of Florida, Department of Neuroscience, 2006-2010
    • PhD, University of Florida, Graduate Program in Biomedical Sciences, Neuroscience, 2006
    • BS, Arizona State University, Microbiology, 1999
    Professional Memberships
    • President, American Society for Neural Therapy and Repair, 2018-2020
    • Fellow, American Society for Neural Therapy and Repair, 2015-Present
    • Cover Image, Molecular Therapy, June 2009, March 2015
    • Julius Axelrod Travel Award, Society for Neuroscience, 2011
    • Alumni Fellowship, University of Florida, 2001-2005
    Honors and Awards
    • American Society for Gene & Cell Therapy
    • The American Society for Neural Therapy and Repair
    • Society for Neuroscience
    Selected Publications
    1. Xiang J, Wang ZH, Ahn EH, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Ju G, Wu S, Ye K. Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies. Proc Natl Acad Sci U S A. 2019;116(18):9094-9102.
    2. Wang ZH, Xiang J, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Wu S, Wang JZ, Ye K. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates delta-Secretase by Upregulating C/EBPbeta in Alzheimer’s Disease. Cell Rep. 2019;28(3):655-669 e655.
    3. Steece-Collier K, Stancati JA, Collier NJ, Sandoval IM, Mercado NM, Sortwell CE, Collier TJ, Manfredsson FP. Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia. Mov Disord. 2019;34(5):697-707.
    4. Sellnow RC, Newman JH, Chambers N, West AR, Steece-Collier K, Sandoval IM, Benskey MJ, Bishop C, Manfredsson FP. Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia. Acta Neuropathol Commun. 2019;7(1):8.
    5. Romoli B, Lozada AF, Sandoval IM, Manfredsson FP, Hnasko TS, Berg DK, Dulcis D. Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption. Biol Psychiatry. 2019;86(5):344-355.
    6. Wang ZH, Wu W, Kang SS, Liu X, Wu Z, Peng J, Yu SP, Manfredsson FP, Sandoval IM, Liu X, Wang JZ, Ye K. BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT. JCI Insight. 2018;3(16).
    7. Wang ZH, Gong K, Liu X, Zhang Z, Sun X, Wei ZZ, Yu SP, Manfredsson FP, Sandoval IM, Johnson PF, Jia J, Wang JZ, Ye K. C/EBPbeta regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease. Nat Commun. 2018;9(1):1784.
    8. Raghunathan R, Polinski NK, Klein JA, Hogan JD, Shao C, Khatri K, Leon D, McComb ME, Manfredsson FP, Sortwell CE, Zaia J. Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway. Mol Cell Proteomics. 2018;17(9):1778-1787.
    9. Manfredsson FP, Tansey MG, Golde TE. Challenges in Passive Immunization Strategies to Treat Parkinson Disease. JAMA Neurol. 2018;75(10):1180-1181.
    10. Manfredsson FP, Luk KC, Benskey MJ, Gezer A, Garcia J, Kuhn NC, Sandoval IM, Patterson JR, O’Mara A, Yonkers R, Kordower JH. Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology. Neurobiol Dis. 2018;112:106-118.

    About Barrow Neurological Institute
    Since our doors opened as a regional specialty center in 1962, we have grown into one of the premier destinations in the world for neurology and neurosurgery. Our experienced, highly skilled, and comprehensive team of neurological specialists can provide you with a complete spectrum of care–from diagnosis through outpatient neurorehabilitation–under one roof. Barrow Neurological Institute: Discover. Educate. Heal.