Ivette Sandoval, PhD, is an associate professor in the Department of Neurobiology at Barrow Neurological Institute.
Dr. Sandoval’s expertise includes the application of gene therapy and gene editing techniques to the nervous system. She is a member of the American Society for Gene & Cell Therapy, The American Society for Neural Therapy and Repair, and the Society for Neuroscience.
Dr. Sandoval earned her doctorate degree in biochemistry and molecular biology from Baylor College of Medicine in Houston. She also completed a postdoctoral fellowship in the Translational Science and Molecular Medicine Department at Michigan State University in East Lansing.
Dr. Sandoval’s research interests include the use of gene editing tools and viral vectors to better understand and potentially treat neurodegenerative diseases. She also studies the etiology of Parkinson’s disease—specifically how aging and the alpha-synuclein protein affect epigenetic mechanisms of midbrain dopamine neurons.
- Postdoctoral Fellowship, Michigan State University, 2013-2016
- PhD, Baylor College of Medicine, Biochemistry and Molecular Biology, 2012
- BS, Universidad Simón Bolívar, Biology, 2001
- American Society for Gene & Cell Therapy
- The American Society for Neural Therapy and Repair
- Society for Neuroscience
- Illumina Sequencing for Michigan State University Researcher’s Award, 2019
- Postdoctoral Fellowship Award, Parkinson’s Disease Foundation, 2016
- John R. Kelsey Jr. Student Speaker Award, Baylor College of Medicine, 2012
- Travel Award, The American Society for Neural Therapy and Repair, 2012
- Travel Award, National Eye Institute, 2011
- Travel Award, American Society for Gene & Cell Therapy, 2011
- C. Joshi Memorial Award, Honorary Mention Poster Presentation, Verna and Marrs McLean Department of Biochemistry Research Conference, 2010
- Outstanding Poster Award, Federation of American Societies for Experimental Biology Summer Research Conference, 2009
- Minority Access to Research Careers Travel Award, Federation of American Societies for Experimental Biology Summer Research Conference, 2009
- Minority Fellowship, Biotechnology Institute, 2008
- Fellowship to Attend “Fundamental Issues in Vision Research: Molecular and Cell Biological Approaches” at Marine Biological Laboratories, National Institutes of Health, 2008
- C. Joshi Memorial Award, Honorary Mention Oral Presentation, Verna and Marrs McLean Department of Biochemistry Research Conference, 2007
- C. Joshi Memorial Award, Third Place Poster Presentation, Verna and Marrs McLean, Department of Biochemistry Research Conference, 2006
- Xiang J, Wang ZH, Ahn EH, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Ju G, Wu S, Ye K. Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies. Proc Natl Acad Sci U S A. 2019;116(18):9094-9102.
- Steece-Collier K, Stancati JA, Collier NJ, Sandoval IM, Mercado NM, Sortwell CE, Collier TJ, Manfredsson FP. Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia. Mov Disord. 2019;34(5):697-707.
- Sellnow RC, Newman JH, Chambers N, West AR, Steece-Collier K, Sandoval IM, Benskey MJ, Bishop C, Manfredsson FP. Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia. Acta Neuropathol Commun. 2019;7(1):8.
- Sandoval IM, Kuhn NM, Manfredsson FP. Multimodal Production of Adeno-Associated Virus. Methods Mol Biol. 2019;1937:101-124
- Benskey MJ, Sandoval IM, Miller K, Sellnow RL, Gezer A, Kuhn NC, Vashon R, Manfredsson FP. Basic Concepts in Viral Vector-Mediated Gene Therapy. Methods Mol Biol. 2019;1937:3-26.
- Sandoval IM, Collier TJ, Manfredsson FP. Design and Assembly of CRISPR/Cas9 Lentiviral and rAAV Vectors for Targeted Genome Editing. Methods Mol Biol. 2019;1937:29-45.
- Wang ZH, Wu W, Kang SS, Liu X, Wu Z, Peng J, Yu SP, Manfredsson FP, Sandoval IM, Liu X, Wang JZ, Ye K. BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT. JCI Insight. 2018;3(16).
- Kang SS, Ahn EH, Zhang Z, Liu X, Manfredsson FP, Sandoval IM, Dhakal S, Iuvone PM, Cao X, Ye K. α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson’s disease. EMBO J. 2018 Jun 15;37(12).
- Wang ZH, Gong K, Liu X, Zhang Z, Sun X, Wei ZZ, Yu SP, Manfredsson FP, Sandoval IM, Johnson PF, Jia J, Wang JZ, Ye K. C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease. Nat Commun. 2018 May 3;9(1):1784.
- Benskey MJ, Sellnow RC, Sandoval IM, Sortwell CE, Lipton JW, Manfredsson FP. Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity. Front Mol Neurosci. 2018 Feb 13;11:36.