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    Jie Wu, MD, PhD

    Professor, Neurobiology (602) 406-3029

    Dr. Jie Wu joined Barrow in 1998 as a principal investigator and as Director of Epilepsy Research. Since 2000 he has overseen several research projects on the physiology, pharmacology, and pathophysiology of neuronal nicotinic acetylcholine receptors (nAChR) using both heterologously expressed and natural nAChRs. Dr. Wu also investigates the epileptogenesis of human gelastic seizures using surgically resected human hypothalamic hamartoma tissue from patients with gelastic seizures. He is a leader in the study of the epileptogenic mechanisms underlying human hypothalamic hamartomas. He has used his experience as an electrophysiologist to make significant contributions to the study of nAChRs.

    Since 2000, Dr. Wu’s laboratory has been published in more than 100 peer-reviewed papers such as Nature Chemistry (1), PNAS (1), Molecular Psychiatry (1), Annals Neurology (2), Trend in Pharmacology Science (1), Journal of Neuroscience (6), among others. His research papers have been cited 2,763 times (as of April 29, 2016), and he carries an h-index of 30 and an i10-index of 79. The research programs that constitute the Wu Laboratory have been funded by the NIH and other foundations including NIHR01 (5), NIHR21 (3), NIHU19 (2), Philip Morris External Research grant (2), Arizona Biomedical Research Commission (3). Dr. Wu has also contributed to six book chapters and owns four United States utility patents. Dr. Wu is an adjunct professor at Arizona State University and a research professor at the University of Arizona Medical College in Phoenix. Dr. Wu is editor in chief of the journal Chemistry and Pharmacology: Open Access and associate editor of Acta Pharmacologica Sinica. He also serves on the editorial board for several scientific journals.

    Dr. Wu pursued postdoctoral training at both the University of New Mexico and Tohoku University School of Medicine in Japan. He received his PhD from Sun Yet-Sen University of Medical Sciences and his MD from Xuzhou Medical College, both in China.

    Education & Training
    • Postdoctoral Fellowship, Tohoku University School of Medicine, Sendai, Japan, 1993-1994
    • Medical Internship, Subsidiary Hospital of Xuzhou Medical College, Xuzhou, China, 1982-1983
    • PhD, Sun Yat-Sen University of Medical Sciences, Guangzhou, China, 1990
    • MD, Xuzhou Medical College, Xuzhou, China, 1983
    Professional Memberships
    • Society for Neuroscience
    • Chinese-American Neuroscientist Society
    • American Epilepsy Society
    • American Society for Pharmacology and Experimental Therapeutics
    • American Physiology Society
    • Translational Neuroscience Society
    Honors and Awards
    • Outstanding Contribution Award, Acta Phamarcologica Sinica, Shanghai, China, 2010
    • Chinese National Nature and Science Award, 2006
    • Beijing Science and Technique Advance Prize, Beijing, China, 2005
    • National Young Physiologist Excellent Thesis Prize, Xi-Jun Zhang Foundation, China, 1992
    • Young Scientist Excellent Thesis Prize, Sun-Yat Sen University of Medical Sciences, China, 1990
    • Young Scientist Excellent Thesis Prize, Sun-Yat Sen University of Medical Sciences, China, 1989
    • Natural Scientific Excellent Thesis Prize, Guangdong Province, China, 1988
    Selected Publications
    1. Zhang HY, Gao M, Liu QR, Bi GH, Li X, Yang HJ, Gardner EL, Wu J, Xi ZX. Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E5007-15.
    2. Liu Q, Xie X,Lukas RJ, St John PA, Wu J. A novel nicotinic mechanism underlies β-amyloid-induced neuronal hyperexcitation. J Neurosci. 2013 Apr 24;33(17):7253-63.
    3. Zhang D, Gao M, Xu D, Shi WX, Gutkin BS, Steffensen SC,Lukas RJ, Wu J. Impact of prefrontal cortex in nicotine-induced excitation of ventral tegmental area dopamine neurons in anesthetized rats. J Neurosci. 2012 Sep 5;32(36):12366-75.
    4. Yang K, Buhlman L, Khan GM, Nichols RA, Jin G, McIntosh JM, Whiteaker P,Lukas RJ, Wu J. Functional nicotinic acetylcholine receptors containing α6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons. J Neurosci. 2011 Feb 16;31(7):2537-48.
    5. Li G, Yang K, Zheng C, Liu Q, Chang Y, Kerrigan JF, Wu J. Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomas. Ann Neurol. 2011 Apr;69(4):664-72.
    6. Gao M, Jin Y, Yang K, Zhang D,Lukas RJ, Wu J. Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area. J Neurosci. 2010 Oct 13;30(41):13814-25.
    7. Liu Q, Huang Y, Xue F, Simard A, DeChon J, Li G, Zhang J, Lucero L, Wang M, Sierks M, Hu G, Chang Y,Lukas RJ, Wu J. A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci. 2009 Jan 28;29(4):918-29.
    8. Wu J, Xu L, Kim DY, Rho JM, St John PA, Lue LF, Coons S, Ellsworth K, Nowak L, Johnson E, Rekate H, Kerrigan JF. Electrophysiological properties of human hypothalamic hamartomas. Ann Neurol. 2005 Sep;58(3):371-82.
    9. Wu J, Kuo YP, George AA, Xu L, Hu J,Lukas RJ. beta-Amyloid directly inhibits human alpha4beta2-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 cells. J Biol Chem. 2004 Sep 3;279(36):37842-51.
    10. Wu J,Fisher RS. Hyperthermic spreading depressions in the immature rat hippocampal slice. J Neurophysiol. 2000 Sep;84(3):1355-60.