Nadine Bakkar, PhD, is an assistant professor in the Department of Neurobiology at Barrow Neurological Institute.
Dr. Bakkar received her doctorate from The Ohio State University in molecular biology in the laboratory of Dr. Denis Guttridge, focusing on NF-kappaB signaling pathways involved in muscle development and regeneration. She completed two postdoctoral fellowships, one at The Ohio State University Comprehensive Cancer Center and one at Barrow Neurological Institute as part of Dr. Robert Bowser’s laboratory.
Dr. Bakkar’s research interests include neurodegenerative diseases specifically amyotrophic lateral sclerosis (ALS), focusing on blood brain and blood-CSF barriers disruptions, as well as changes in RNA metabolism and transport that contribute to ALS pathogenesis.
Dr Bakkar is a member of the Society of Neuroscience (SFN).
- Postdoctoral Fellowship, Barrow Neurological Institute, 2012-2015
- Postdoctoral Fellowship, The Ohio State University Comprehensive Cancer Center, 2008-2012
- PhD, The Ohio State University, Molecular Biology, 2008
- MS, American University of Beirut, Biology, Beirut, Lebanon, 2001
- BS, American University of Beirut, Biology, 1999
- Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R. RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. Mol Cell Biol. Jul 2015;35(14):2385-2399.
- Bakkar N, Boehringer A, Bowser R. Use of biomarkers in ALS drug development and clinical trials. Brain Res. May 14 2015;1607:94-107.
- Balkhi MY, Iwenofu OH, Bakkar N, Ladner KJ, Chandler DS, Houghton PJ, London CA, Kraybill W, Perrotti D, Croce CM, Keller C, Guttridge DC. miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR. Sci Signal. Jul 30 2013;6(286):ra63.
- Parker MH, von Maltzahn J, Bakkar N, Al-Joubori B, Ishibashi J, Guttridge D, Rudnicki MA. MyoD-dependent regulation of NF-kappaB activity couples cell-cycle withdrawal to myogenic differentiation. Skelet Muscle. 2012;2(1):6.
- Bakkar N, Ladner K, Canan BD, Liyanarachchi S, Bal NC, Pant M, Periasamy M, Li Q, Janssen PM, Guttridge DC. IKKalpha and alternative NF-kappaB regulate PGC-1beta to promote oxidative muscle metabolism. J Cell Biol. Feb 20 2012;196(4):497-511.
- Peterson JM, Bakkar N, Guttridge DC. NF-kappaB signaling in skeletal muscle health and disease. Curr Top Dev Biol. 2011;96:85-119.
- Dahlman JM, Bakkar N, He W, Guttridge DC. NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development. J Biol Chem. Feb 19 2010;285(8):5479-5487.
- Bakkar N, Guttridge DC. NF-kappaB signaling: a tale of two pathways in skeletal myogenesis. Physiol Rev. Apr 2010;90(2):495-511.
- Dahlman JM, Wang J, Bakkar N, Guttridge DC. The RelA/p65 subunit of NF-kappaB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesis. J Cell Biochem. Jan 1 2009;106(1):42-51.
- Bakkar N, Wang J, Ladner KJ, Wang H, Dahlman JM, Carathers M, Acharyya S, Rudnicki MA, Hollenbach AD, Guttridge DC. IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis. J Cell Biol. Feb 25 2008;180(4):787-802.