Rita Sattler, PhD, is an associate professor in the Department of Neurobiology at Barrow Neurological Institute.
Dr. Sattler received her master’s and doctorate degrees in neurophysiology from the University of Toronto in Toronto, Canada. She completed a postdoctoral fellowship in the Department of Neuroscience at Johns Hopkins University Medical School in Baltimore, Maryland. Dr. Sattler stayed at Johns Hopkins University and attained the academic rank of assistant professor of Neurology, with a secondary appointment in the Brain Science Institute at the Johns Hopkins University School of Medicine.
Dr. Sattler is a member of the American Society for Neuroscience and the American Society for Neurochemistry. She is the recipient of several awards and fellowships, including the Governor’s Gold Medal for the highest academic achievement in graduate studies at the University of Toronto, a Human Frontier Science Program Long-term Fellowship, and a Howard Hughes Postdoctoral Fellowship. She currently serves as grant reviewer for several national and international disease foundations as well as the NIH.
Dr. Sattler’s research focuses on studies of synaptic biology in health and disease. She employs human patient-derived induced pluripotent stem cells to elucidate the mechanisms of neuronal cell death in numerous neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Dr. Sattler is principal investigator and co-investigator of numerous active grants from the NIH/NINDS as well as several disease foundations, including the ALS Association (ALSA), the Muscular Dystrophy Association (MDA) and the Robert Packard Center for ALS Research.
- Postdoctoral Fellowship, Johns Hopkins University, Department of Neuroscience, 1999-2004
- PhD, University of Toronto, Physiology, 1999
- MS, University of Toronto, Physiology, 1996
- BS, Technical University of Mannheim, Chemical and Biotechnology Engineering, 1993
- Society for Neuroscience
- American Society for Neurochemistry
- Volunteer of the year, The Robert Packard Center for ALS Research at Johns Hopkins, 2010
- Postdoctoral Fellowship, Howard Hughes Medical Institute, 2003-2004
- Governor General’s Gold Medal for the Highest Academic Achievement in Graduate Studies, University of Toronto, Toronto, Canada, 2000
- Long Term Fellowship, Human Frontier Science Program, 2000-2003
- Zhang PW, Haidet-Phillips AM, Pham JT, Lee Y, Huo Y, Tienari PJ, Maragakis NJ, Sattler R, Rothstein JD. Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology. Glia. Aug 21 2015.
- Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD. The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature. Sep 3 2015;525(7567):56-61.
- Mendez EF, Sattler R. Biomarker development for C9orf72 repeat expansion in ALS. Brain Res. May 14 2015;1607:26-35.
- Li Y, Balasubramanian U, Cohen D, Zhang PW, Mosmiller E, Sattler R, Maragakis NJ, Rothstein JD. A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells. PLoS One. 2015;10(3):e0118266.
- Ghosh M, Lane M, Krizman E, Sattler R, Rothstein JD, Robinson MB. Transcription Factor Pax6 Contributes to Induction of GLT-1 Expression in Astrocytes Through an Interaction with a Distal Enhancer Element. J Neurochem. Oct 20 2015.
- Haeusler AR, Donnelly CJ, Periz G, Simko EA, Shaw PG, Kim MS, Maragakis NJ, Troncoso JC, Pandey A, Sattler R, Rothstein JD, Wang J. C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature. Mar 13 2014;507(7491):195-200.
- Donnelly CJ, Grima JC, Sattler R. Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets? Neurodegener Dis Manag. 2014;4(6):417-437.
- Abazyan S, Yang EJ, Abazyan B, Xia M, Yang C, Rojas C, Slusher B, Sattler R, Pletnikov M. Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism. J Neurosci Res. Dec 2014;92(12):1659-1668.
- Roybon L, Lamas NJ, Garcia-Diaz A, Yang EJ, Sattler R, Jackson-Lewis V, Kim YA, Kachel CA, Rothstein JD, Przedborski S, Wichterle H, Henderson CE. Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes. Cell Rep. Sep 12 2013;4(5):1035-1048.
- Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennett CF, Blackshaw S, Sattler R, Rothstein JD. RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron. Oct 16 2013;80(2):415-428.