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  • Shwetal Mehta, PhD

    Associate Professor, Neurobiology (602) 406-3288

    Dr. Shwetal Mehta received her MS from Tata Institute of Fundamental Research, India, in Molecular Biology. She earned her PhD in Molecular Genetics and Microbiology from The University of Texas at Austin in 2003.

    She completed her postdoctoral work in the Charles Stiles Laboratory at the Dana-Farber Cancer Institute and Harvard Medical School. Her postdoctoral work was focused on the identification of a potential therapeutic target for high-grade gliomas. She joined the Barrow Brain Tumor Center as an principal investigator in January of 2013.

    Education & Training
    • Research Fellow, Dana-Farber Cancer Institute, Harvard Medical School, 2005-2010
    • Postdoctoral Fellow, University of Texas at Austin, 2003-2004
    • PhD, Molecular Genetics and Microbiology, University of Texas at Austin, 2003
    • MS, Molecular Biology, Tata Institute of Fundamental Research (TIFR), Mumbai, India, 1998
    • BS, Biochemistry and Microbiology, University of Mumbai, Mumbai, India, 1994
    Honors and Awards
    • Best Mature Project Award at the DFCI Cancer Biology Retreat, 2010
    • Ruth L. Kirschstein National Research Service Award,  2006-2009
    • William Livingston Fellowship, 2003-2004
    • Outstanding Doctoral Dissertation Honorable Mention Award, 2004
    • L. Joe Berry Memorial Scholarship, 2003-2004
    • Patricia Ruth Aston Memorial Award, 2002-2003
    • University Continuing Fellowship, 2002-2003
    • University Continuing Fellowship, 2001-2002
    • Charles Ely Lankford Scholarship, 2001-2002
    Selected Publications
    1. Singh SK, Fiorelli R, Kupp R, Rajan S, Szeto E, Lo Cascio C, Maire CL, Sun Y, Alberta JA, Eschbacher JM, Ligon KL, Berens ME, Sanai N, Mehta S. Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-beta Pathway. Cell Rep. 2016;16(4):950-966.
    2. Kupp R, Shtayer L, Tien AC, Szeto E, Sanai N, Rowitch DH, Mehta S. Lineage-Restricted OLIG2-RTK Signaling Governs the Molecular Subtype of Glioma Stem-like Cells. Cell Rep. 2016;16(11):2838-2845.
    3. Meijer DH, Sun Y, Liu T, Kane MF, Alberta JA, Adelmant G, Kupp R, Marto JA, Rowitch DH, Nakatani Y, Stiles CD, Mehta S. An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells. J Neurosci. 2014;34(25):8507-8518.
    4. Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien AC, Fu H, Petryniak MA, Potter GB, Liu Z, Powers JF, Runquist IS, Rowitch DH, Stiles CD. Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron. 2011;69(5):906-917.
    5. Mehta S, Huillard E, Kesari S, Maire CL, Golebiowski D, Harrington EP, Alberta JA, Kane MF, Theisen M, Ligon KL, Rowitch DH, Stiles CD. The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell. 2011;19(3):359-371.
    6. Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 2007;53(4):503-517.

    About Barrow Neurological Institute
    Since our doors opened as a regional specialty center in 1962, we have grown into one of the premier destinations in the world for neurology and neurosurgery. Our experienced, highly skilled, and comprehensive team of neurological specialists can provide you with a complete spectrum of care–from diagnosis through outpatient neurorehabilitation–under one roof. Barrow Neurological Institute: Discover. Educate. Heal.