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    Yongchang Chang, MD, PhD

    Associate Professor, Neurobiology (602) 406-6192

    Dr. Yongchang Chang is an associate professor in the Division of Neurobiology at Barrow Neurological Institute. He received his medical degree in 1982 from Sun Yat-sen University of Medical Sciences, Guangzhou, China, and his PhD in Physiology and Biophysics in 1998 from the University of Alabama at Birmingham.

    Dr. Chang has over two decades of experience studying the structure-function relationship of ligand-gated ion channels. He has published 34 peer-reviewed research papers, 4 review papers, and 4 book chapters. Dr. Chang has a current NIH R01 grant to study dynamic structural basis for the mechanism of activation and antagonism of GABAC receptors (PI) and a current NIH U19 grant to develop nicotinic ligands as new antidepressants (co-project leader). He has also successfully completed NIH-supported research to investigate the role of GABA receptor-mediated excitation in the epilepsy of human hypothalamic hamartoma (co-investigator) and Arizona Biomedical Research Commission-supported research to study GABA receptor structure-function relationship.

    Education & Training
    • Postdoctoral Fellowship, University of Alabama at Birmingham, Department of Neurobiology and Physiology & Biophysics, 1998-2003
    • PhD, University of Alabama at Birmingham, Department of Physiology and Biophysics, 1998
    • Master of Medicine, Sun Yat-sen University of Medical Sciences, Department of Pathophysiology, Guangzhou, China, 1986
    • Bachelor of Medicine (MD equivalent), Sun Yat-sen University of Medical Sciences, 1982
    Professional Memberships
    • Society for Neuroscience
    • Biophysical Society
    Honors and Awards
    • NIDDK Postdoctoral Training Grant, 2000-2003
    • Outstanding Teacher in the Higher Educational System of Guangdong Province, China, 1988
    Selected Publications
    1. Xu X, Sepich C, Lukas RJ, Zhu G, Chang Y. Emamectin is a non-selective allosteric activator of nicotinic acetylcholine receptors and GABAA/C receptors. Biochem Biophys Res Commun. May 13 2016;473(4):795-800.
    2. Ji HL, Nie HG, Chang Y, Lian Q, Liu SL. CPT-cGMP Is A New Ligand of Epithelial Sodium Channels. Int J Biol Sci. 2016;12(4):359-366.
    3. Zhang Q, Du Y, Zhang J, Xu X, Xue F, Guo C, Huang Y, Lukas RJ, Chang Y. Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human alpha7 Nicotinic Receptor. PLoS One. 2015;10(9):e0137588.
    4. Yan H, Pan N, Xue F, Zheng Y, Li C, Chang Y, Xu Z, Yang H, Zhang J. The coupling interface and pore domain codetermine the single-channel activity of the alpha7 nicotinic receptor. Neuropharmacology. Aug 2015;95:448-458.
    5. Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA. Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites. J Biol Chem. Feb 27 2015;290(9):5241-5255.
    6. Feng B, Lin X, Zheng K, Qian K, Chang Y, Du Y. Transcriptome and expression profiling analysis link patterns of gene expression to antennal responses in Spodoptera litura. BMC Genomics. 2015;16:269.
    7. Huang Y, Chang Y. Regulation of pancreatic islet beta-cell mass by growth factor and hormone signaling. Prog Mol Biol Transl Sci. 2014;121:321-349.
    8. Eaton JB, Lucero LM, Stratton H, Chang Y, Cooper JF, Lindstrom JM, Lukas RJ, Whiteaker P. The unique alpha4+/-alpha4 agonist binding site in (alpha4)3(beta2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology versus the (alpha4)2(beta2)3 subtype. J Pharmacol Exp Ther. Jan 2014;348(1):46-58.
    9. Wu W, Shi C, Ma F, Balducci J, Huang H, Ji HL, Chang Y, Huang Y. Structural and functional characterization of two alternative splicing variants of mouse Endothelial Cell-Specific Chemotaxis Regulator (ECSCR). Int J Mol Sci. 2012;13(4):4920-4936.
    10. Lu J, Li C, Shi C, Balducci J, Huang H, Ji HL, Chang Y, Huang Y. Identification of novel splice variants and exons of human endothelial cell-specific chemotaxic regulator (ECSCR) by bioinformatics analysis. Comput Biol Chem. Dec 2012;41:41-50.