Speech Analysis in ALS Patients with and without Cognitive Abnormalities: Evaluation of Sensitivity and Disease Progression
The purpose of this study is to determine whether speech and language measures can be used to detect cognitive changes, such as alterations in memory or thinking, in patients with amyotrophic lateral sclerosis (ALS).
By detecting cognitive changes earlier in the ALS disease course, we may be able to implement more tailored clinical trial designs, as well as provide better clinical care to ALS patients.
There are five visits required for this study. These are scheduled at the same time as regularly scheduled visits to the Barrow ALS Clinic, and occur approximately every 3 months. Participants also complete speech and language assessments at home each week. Overall, participants may be in the research study for about 12 months.
Principal Investigators: Jeremy Shefner, MD, PhD, Julie Liss, PhD, and Visar Berisha, PhD