StATins Use in intRacereberal hemorrhage patieNts (SATURN)
This research is being done to find out if it is better to continue or discontinue statin drugs in people who had a brain hemorrhage while taking a statin drug. Statin drugs help prevent heart disease and ischemic stroke. Ischemic strokes are caused by a clot in a blood vessel that blocks blood flow to a part of the brain. However, statin drugs might increase the risk of having another brain hemorrhage in some people that already had a brain hemorrhage. Many physicians are not sure what to do about using statin drugs after a brain hemorrhage. They are not sure if it is better to continue or stop treatment with a statin drug after a brain hemorrhage.
Some people may have an increased likelihood of having another brain hemorrhage while taking statin drugs. This may be due to people having certain genes. Genes are made up of DNA. DNA contains information that determines in part the traits, such as eye color, height, or disease risk, that are passed on from parent to child. Genes provide an instruction book for making proteins that make a person unique. This “uniqueness” includes a person’s diseases, response to drugs, or other problems.
Having certain Apolipoprotein-E genes might make some people more likely to have another brain hemorrhage while taking statin drugs. This study is also being done to see if you have one of these Apolipoprotein-E genes and to examine whether having these genes actually increases the risk of brain hemorrhage in people who take statin drugs.
Approximately 1456 people with brain hemorrhage will take part in this study