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Thecal Sac Database

Quantitative Analysis of Thecal Sac Volume and Morphology as a Diagnostic Tool in Intracranial Hypotension

The purpose of this study is to test the effectiveness of a new imaging tool to increase the confidence in diagnosis of spontaneous intracranial hypotension (SIH). SIH is a condition in which the fluid pressure inside the skull is lower than normal. SIH often causes severe headaches, as well as nausea, vertigo, ringing in the ears, blurred vision, and tingling of the arms.

Diagnosis of SIH is difficult. Many individuals are diagnosed through an imaging exam of the spinal cord and cerebrospinal fluid (CSF) called a myelography. The aim of the myelography is to look for CSF leakage, which is commonly considered a cause of SIH. However, CSF leakage is not always detectable or the main cause of SIH.

In some patients, SIH may be caused by an increase in the size of CSF space or connective tissue insufficiency, rather than changes in CSF volume. We hypothesize that examining the change in size/shape of CSF space will be a more effective method to diagnosing SIH. 

Approximately 30 healthy control participants will enroll in this research study. 

If you choose to take part in this study, the investigator or study staff will review your medical history and perform a spine MRI. The MRI will undergo image analysis, CSF volume, and shape and size analysis. 

Closed for enrollment
Phoenix, Arizona
Total Participants
Primary Sponsor
Spinal CSF Leak Foundation
Additional Sponsor(s)
Barrow Neurological Foundation