An-Chi Tien, PhD
An-Chi Tien, PhD, is an assistant professor in the Department of Neurobiology at Barrow Neurological Institute. He works in the Ivy Brain Tumor Center.
Dr. Tien’s expertise includes developmental biology and genetics, particularly applied to neuro-oncology. Dr. Tien is a member of the American Brain Tumor Association Alumni Research Network, the American Society of Clinical Oncology, and the Society for Neuro-Oncology.
Dr. Tien earned his doctorate degree in developmental biology from the Baylor College of Medicine in Houston. He completed his postdoctoral research fellowship at University of California San Francisco’s Institute for Regenerative Medicine.
Dr. Tien’s research focuses on establishing and optimizing pharmacodynamic tests to support clinical trials for patients with brain tumors and to better understand tumor resistance mechanisms.
Richard Dortch, PhD
Richard Dortch, PhD, is an associate professor in the Division of Neuroimaging Research at Barrow Neurological Institute.
Dr. Dortch’s expertise includes radiological sciences and biomedical engineering. He is a member of the American Academy of Neurology and the International Society for Magnetic Resonance in Medicine.
Dr. Dortch earned his master’s and doctorate degrees in biomedical engineering from Vanderbilt University in Nashville, Tennessee. He completed a postdoctoral research fellowship in the Department of Radiology and Radiological Sciences at Vanderbilt University Medical Center.
Dr. Dortch’s research interests include developing, optimizing, and validating quantitative MRI methods for the brain, spinal cord, and nerves. He aims to apply these methods in patient populations to guide surgery, improve diagnostics, expand our understanding of disease progression, and serve as biomarkers of therapeutic response.
Ivette Sandoval, PhD
Ivette Sandoval, PhD, is an associate professor in the Department of Neurobiology at Barrow Neurological Institute.
Dr. Sandoval’s expertise includes the application of gene therapy and gene editing techniques to the nervous system. She is a member of the American Society for Gene & Cell Therapy, The American Society for Neural Therapy and Repair, and the Society for Neuroscience.
Dr. Sandoval earned her doctorate degree in biochemistry and molecular biology from Baylor College of Medicine in Houston. She also completed a postdoctoral fellowship in the Translational Science and Molecular Medicine Department at Michigan State University in East Lansing.
Dr. Sandoval’s research interests include the use of gene editing tools and viral vectors to better understand and potentially treat neurodegenerative diseases. She also studies the etiology of Parkinson’s disease—specifically how aging and the alpha-synuclein protein affect epigenetic mechanisms of midbrain dopamine neurons.
Fredric Manfredsson, PhD
Fredric Manfredsson, PhD, is an associate professor in the Department of Neurobiology at Barrow Neurological Institute.
Dr. Manfredsson’s expertise includes microbiology and virology, with a special interest in gene therapy for Parkinson disease and other neurodegenerative diseases. He is a member of the American Society for Gene & Cell Therapy, The American Society for Neural Therapy and Repair, and the Society for Neuroscience.
Dr. Manfredsson earned his doctorate degree in neuroscience from the University of Florida in Gainesville, where he also completed a postdoctoral fellowship in neuroscience.
Dr. Manfredsson’s research has multiple focuses. One aspect is to better understand the role of the protein alpha-synuclein in both healthy cells and those affected by Parkinson’s disease. His research also emphasizes understanding the symptomology of the disease, with a focus on the treatment of levodopa-induced dyskinesia and nonmotor symptoms experienced by nearly all patients with Parkinson’s disease.