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Research project: Mechanisms of synaptopathy in C9orf72 ALS/FTD using hiPSC-neurons and novel mouse models of C9orf72. Techniques applied to this project include confocal microscopy, live longitudinal survival studies of hiPSC-neurons, and live measurements of neuronal Ca homeostasis.
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease
Date: 02/2021
Authors: Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser
Generation of two induced pluripotent stem cell (iPSC) lines from an ALS patient with simultaneous mutations in KIF5A and MATR3 genes
Date: 01/2021
Authors: David X. Medina, Ashley Boehringer, Marissa Dominick, Ileana Lorenzini, Sara Saez-Atienzar, Erik P. Pioro, Rita Sattler, Bryan Traynor, Robert Bowser
Glycolysis Upregulation Is Neuroprotective As A Compensatory Mechanism In Als
Date: 06/2019
Authors: Ernesto Manzo, Ileana Lorenzini, Dianne Barrameda, Abigail G. O'Conner, Jordan M. Barrows, Alexander Starr, Tina Kovalik, Benjamin E. Rabichow, Erik M. Lehmkuhl, Dakotah D. Shreiner, Archi Joardar, Jean Charles Liévens, Robert Bowser, Rita Sattler, Daniela C. Zarnescu
Adar2 Mislocalization And Widespread Rna Editing Aberrations In C9Orf72-Mediated Als/Ftd
Date: 01/2019
Authors: Stephen Moore, Eric Alsop, Ileana Lorenzini, Alexander Starr, Benjamin E. Rabichow, Emily Mendez, Jennifer L. Levy, Camelia Burciu, Rebecca Reiman, Jeannie Chew, Veronique V. Belzil, Dennis W. Dickson, Janice Robertson, Kim A. Staats, Justin K. Ichida, Leonard Petrucelli, Kendall Van Keuren-Jensen, Rita Sattler
Reactivation Of Nonsense-Mediated Mrna Decay Protects Against C9Orf72 Dipeptide-Repeat Neurotoxicity
Date: 01/2019
Authors: Wangchao Xu, Puhua Bao, Xin Jiang, Haifang Wang, Meiling Qin, Ruiqi Wang, Tao Wang, Yi Yang, Ileana Lorenzini, Lujian Liao, Rita Sattler, Jin Xu
- English
Research project: Mechanisms of synaptopathy in C9orf72 ALS/FTD using hiPSC-neurons and novel mouse models of C9orf72. Techniques applied to this project include confocal microscopy, live longitudinal survival studies of hiPSC-neurons, and live measurements of neuronal Ca homeostasis.
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease
Date: 02/2021
Authors: Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser
Generation of two induced pluripotent stem cell (iPSC) lines from an ALS patient with simultaneous mutations in KIF5A and MATR3 genes
Date: 01/2021
Authors: David X. Medina, Ashley Boehringer, Marissa Dominick, Ileana Lorenzini, Sara Saez-Atienzar, Erik P. Pioro, Rita Sattler, Bryan Traynor, Robert Bowser
Glycolysis Upregulation Is Neuroprotective As A Compensatory Mechanism In Als
Date: 06/2019
Authors: Ernesto Manzo, Ileana Lorenzini, Dianne Barrameda, Abigail G. O'Conner, Jordan M. Barrows, Alexander Starr, Tina Kovalik, Benjamin E. Rabichow, Erik M. Lehmkuhl, Dakotah D. Shreiner, Archi Joardar, Jean Charles Liévens, Robert Bowser, Rita Sattler, Daniela C. Zarnescu
Adar2 Mislocalization And Widespread Rna Editing Aberrations In C9Orf72-Mediated Als/Ftd
Date: 01/2019
Authors: Stephen Moore, Eric Alsop, Ileana Lorenzini, Alexander Starr, Benjamin E. Rabichow, Emily Mendez, Jennifer L. Levy, Camelia Burciu, Rebecca Reiman, Jeannie Chew, Veronique V. Belzil, Dennis W. Dickson, Janice Robertson, Kim A. Staats, Justin K. Ichida, Leonard Petrucelli, Kendall Van Keuren-Jensen, Rita Sattler
Reactivation Of Nonsense-Mediated Mrna Decay Protects Against C9Orf72 Dipeptide-Repeat Neurotoxicity
Date: 01/2019
Authors: Wangchao Xu, Puhua Bao, Xin Jiang, Haifang Wang, Meiling Qin, Ruiqi Wang, Tao Wang, Yi Yang, Ileana Lorenzini, Lujian Liao, Rita Sattler, Jin Xu
- English