The Mehta Laboratory studies the biology of malignant gliomas, including glioblastoma, anaplastic astrocytoma, and oligodendrogliomas. Specifically, we are interested in identifying the signaling pathways that are critical for the survival of therapy-resistant, stem-like and progenitor-like glioma cells in these tumors.
Our goal is to understand the differences between normal stem cells and cancerous stem-like cells. We hope to use this information to precisely target cancer cells.
The three main questions that we hope to answer with our research are:
- How do glioma cells exploit the normal functions of neural stem cells to grow and infiltrate regions of normal brain tissue?
- How do neurodevelopmental factors that play important role in cell fate decisions affect the molecular subtype identity and survival pathways in glioma stem-like cells?
- What is the role of chromatin remodelers in the differential epigenetic regulation of normal progenitor cells and glioma stem-like cells?