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  • Selected Publications: Ducruet Laboratory

    1. Ahmad S, Khan SA, Kindelin A, Mohseni T, Bhatia K, Hoda MN, Ducruet AF. Acetyl-11-keto-β-boswellic acid (AKBA) Attenuates Oxidative Stress, Inflammation, Complement Activation and Cell Death in Brain Endothelial Cells Following OGD/Reperfusion. Neuromolecular Med. 2019 Dec;21(4):505-516. doi: 10.1007/s12017-019-08569-z. Epub 2019 Sep 12.PMID: 31515728
    2. Ahmad S, Kindelin A, Khan SA, Ahmed M, Hoda MN, Bhatia K, Ducruet AF. C3a Receptor Inhibition Protects Brain Endothelial Cells Against Oxygen-glucose Deprivation/Reperfusion.  Exp Neurobiol. 2019 Apr;28(2):216-228. doi: 10.5607/en.2019.28.2.216. Epub 2019 Apr 30.PMID: 31138990
    3. Ahmad S, Pandya C, Kindelin A, Bhatia K, Chaudhary R, Dwivedi AK, Eschbacher JM, Liu Q, Waters MF, Hoda MN, Ducruet AF. C3a Receptor Antagonist Therapy is Protective with or without Thrombolysis in Murine Thromboembolic StrokeBr J Pharmacol. 2020 Jan 24. doi: 10.1111/bph.14989. [Epub ahead of print] PMID: 31975437
    4. Ahmad S, Bhatia K, Kindelin A, Ducruet AF. The Role of Complement C3a Receptor in Stroke. Neuromolecular Med. 2019 May 17. 21(4):467-473. doi: 10.1007/s12017-019-08545-7. PMID:31102134
    5. Zhao XJ, Larkin TM, Lauver MA, Ahmad S, Ducruet AF. Tissue plasminogen activator mediates deleterious complement cascade activation in stroke. PLoS One. 2017;12(7):e0180822.
    6. Ducruet AF, Zacharia BE, Sosunov SA, Gigante PR, Yeh ML, Gorski JW, Otten ML, Hwang RY, DeRosa PA, Hickman ZL, Sergot P, Connolly ES, Jr. Complement inhibition promotes endogenous neurogenesis and sustained anti-inflammatory neuroprotection following reperfused stroke. PLoS One. 2012;7(6):e38664.
    7. Ducruet AF, DeRosa PA, Zacharia BE, Sosunov SA, Connolly ES, Jr., Weinstein DE. GM1485, a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke. J Neurosci Res. 2012;90(7):1413-1423.
    8. Ducruet AF, Sosunov SA, Zacharia BE, Gorski J, Yeh ML, Derosa P, Cohen G, Gigante PR, Connolly ES, Jr. The Neuroprotective Effect of Genetic Mannose-binding Lectin Deficiency is not Sustained in the Sub-acute Phase of Stroke. Transl Stroke Res. 2011;2(4):588-599.
    9. Ducruet AF, Sosunov SA, Visovatti SH, Petrovic-Djergovic D, Mack WJ, Connolly ES, Jr., Pinsky DJ. Paradoxical exacerbation of neuronal injury in reperfused stroke despite improved blood flow and reduced inflammation in early growth response-1 gene-deleted mice. Neurol Res. 2011;33(7):717-725.
    10. Ducruet AF, Mack WJ, Mocco J, Hoh DJ, Coon AL, D’Ambrosio AL, Winfree CJ, Pinsky DJ, Connolly ES, Jr. Preclinical evaluation of postischemic dehydroascorbic Acid administration in a large-animal stroke model. Transl Stroke Res. 2011;2(3):399-403.
    11. Ducruet AF, Zacharia BE, Hickman ZL, Grobelny BT, Yeh ML, Sosunov SA, Connolly ES, Jr. The complement cascade as a therapeutic target in intracerebral hemorrhage. Exp Neurol. 2009;219(2):398-403.
    12. Ducruet AF, Hassid BG, Mack WJ, Sosunov SA, Otten ML, Fusco DJ, Hickman ZL, Kim GH, Komotar RJ, Mocco J, Connolly ES. C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent. J Cereb Blood Flow Metab. 2008;28(5):1048-1058.

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