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    Publications: Chang Lab

    1. Zhang J, Xue F, Whiteaker P, Li C, Wu W, Shen B, Huang Y, Lukas RJ, Chang Y.Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness. J Biol Chem. Jul 15 2011;286(28):25331-25340.
    2. Li C, Wen A, Shen B, Lu J, Huang Y, Chang Y. FastCloning: a highly simplified, purification-free, sequence- and ligation-independent PCR cloning method. BMC Biotechnol. 2011;11:92.
    3. Dash B, Chang Y, Lukas RJ. Reporter mutation studies show that nicotinic acetylcholine receptor (nAChR) alpha5 Subunits and/or variants modulate function of alpha6*-nAChR. J Biol Chem. Nov 4 2011;286(44):37905-37918.
    4. Zhang J, Xue F, Chang Y. Agonist- and antagonist-induced conformational changes of loop F and their contributions to the rho1 GABA receptor function. J Physiol. Jan 15 2009;587(Pt 1):139-153.
    5. Liu Q, Huang Y, Xue F, Simard A, DeChon J, Li G, Zhang J, Lucero L, Wang M, Sierks M, Hu G, Chang Y, Lukas RJ, Wu J. A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci. Jan 28 2009;29(4):918-929.
    6. Zhang J, Xue F, Chang Y. Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors. Mol Pharmacol. Oct 2008;74(4):941-951.
    7. Wu J, DeChon J, Xue F, Li G, Ellsworth K, Gao M, Liu Q, Yang K, Zheng C, He P, Tu J, Kim do Y, Rho JM, Rekate H, Kerrigan JF, Chang Y. GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas. Exp Neurol. Oct 2008;213(2):397-404.
    8. Chen Y, Reilly K, Chang Y. Evolutionarily conserved allosteric network in the Cys loop family of ligand-gated ion channels revealed by statistical covariance analyses. J Biol Chem. Jun 30 2006;281(26):18184-18192.
    9. Sedelnikova A, Smith CD, Zakharkin SO, Davis D, Weiss DS, Chang Y. Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model. J Biol Chem. Jan 14 2005;280(2):1535-1542.
    10. Chang Y, Weiss DS. Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism. Nat Neurosci. Nov 2002;5(11):1163-1168.

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    Since our doors opened as a regional specialty center in 1962, we have grown into one of the premiere destinations in the world for neurology and neurosurgery. Our experienced, highly skilled, and comprehensive team of neurological specialists can provide you with a complete spectrum of care–from diagnosis through outpatient neurorehabilitation–under one roof. Barrow Neurological Institute: Discover. Educate. Heal.