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    Theresa Grebe, MD

    Clinical Geneticist (602) 406-3560

    Dr. Theresa Grebe is a clinical geneticist with the Children’s Health Center Phoenix Genetics Program at Phoenix Children’s Hospital in the Division of Genetics and Metabolism. She evaluates and treats children with genetic conditions, including birth defects and developmental abnormalities.

    She has a particular interest in craniofacial and skeletal anomalies, as well as neurogenetic disorders, specifically autism. She is a co-investigator in a genetic study of autism with the Translational Genomics Research Institute (TGen) and the Southwest Autism Research and Resource Center (SARRC), where she serves as a research consultant.

    Dr. Grebe received her medical training at the Pennsylvania State University College of Medicine and completed her pediatric training in the Phoenix Hospitals Affiliated Pediatric Program, where she also served as chief resident. She was a Flinn Foundation Scholar during her medical genetics fellowship with the University of Arizona College of Medicine and St. Joseph’s Hospital. She is also an associate professor of clinical pediatrics at the University of Arizona College of Medicine.

    Dr. Grebe has completed clinical and laboratory research, and has presented and published on several genetic conditions, including cystic fibrosis and chromosome 7p deletion, and Pallister-Hall, cardio-facio-cutaneous, Prader-Willi, and Williams syndromes. She is certified in clinical genetics by the American Board of Medical Genetics and in general pediatrics by the American Board of Pediatrics.

    To request an appointment at the Barrow Cleft and Craniofacial Center, please call (602) 406-3560.

    Education & Training
    • Fellowship, University of Arizona College of Medicine, Genetics, 1989-1992
    • Chief Residency, Phoenix Hospitals Affiliated Pediatric Program, Pediatrics, 1988-1989
    • Resident, Phoenix Hospitals Affiliated Pediatric Program, 1986-1989
    • MD, Pennsylvania State University College of Medicine, 1986
    Professional Memberships
    • American Society of Human Genetics
    • American Academy of Pediatrics
    • Western Society of Pediatric Research
    • American College of Medical Genetics
    • American Medical Association
    • Mountain States Regional Genetics Services Network
    • Arizona State Genetics Advisory Committee
    Honors and Awards
    • Resident Teaching Award, Phoenix Hospitals Affiliated Residency Program, 1999
    • March of Dimes Medical Student Research Fellowship, 1983
    Selected Publications
    1. Pedersen A, Pettygrove S, Meaney FJ, Mancilla K, Gotschall K, Kessler DB, Grebe TA, et al. Prevalence of autism spectrum disorders in Hispanic and non-Hispanic white children. Pediatrics. Mar 2012;129(3):e629-635.
    2. Alter MD, Kharkar R, Ramsey KE, Craig DW, Melmed RD, Grebe TA, et al. Autism and increased paternal age related changes in global levels of gene expression regulation.PLoS One. 2011;6(2):e16715.
    3. Dhar SU, del Gaudio D, German JR, Peters SU, Ou Z, Bader PI, Berg JS, Blazo M, Brown CW, Graham BH, Grebe TA, et al. 22q13.3 deletion syndrome: clinical and molecular analysis using array CGH. Am J Med Genet A. Mar 2010;152A(3):573-581.
    4. Messiaen L, Yao S, Brems H, Callens T, Sathienkijkanchai A, Denayer E, Spencer E, Arn P, Babovic-Vuksanovic D, Bay C, Bobele G, Cohen BH, Escobar L, Eunpu D, Grebe T, et al. Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome. JAMA. Nov 18 2009;302(19):2111-2118.
    5. Brunetti-Pierri N, Berg JS, Scaglia F, Belmont J, Bacino CA, Sahoo T, Lalani SR, Graham B, Lee B, Shinawi M, Shen J, Kang SH, Pursley A, Lotze T, Kennedy G, Lansky-Shafer S, Weaver C, Roeder ER, Grebe TA, et al. Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities. Nat Genet. Dec 2008;40(12):1466-1471.
    6. del Gaudio D, Fang P, Scaglia F, Ward PA, Craigen WJ, Glaze DG, Neul JL, Patel A, Lee JA, Irons M, Berry SA, Pursley AA, Grebe TA, et al. Increased MECP2 gene copy number as the result of genomic duplication in neurodevelopmentally delayed males.Genet Med. Dec 2006;8(12):784-792.
    7. Armstrong L, Abd El Moneim A, Aleck K, Aughton DJ, Baumann C, Braddock SR, Gillessen-Kaesbach G, Graham JM, Jr., Grebe TA, et al. Further delineation of Kabuki syndrome in 48 well-defined new individuals. Am J Med Genet A. Jan 30 2005;132A(3):265-272.
    8. Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufai S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, et al. Human chromosome 7: DNA sequence and biology. Science. May 2 2003;300(5620):767-772.
    9. Nakabayashi K, Fernandez BA, Teshima I, Shuman C, Proud VK, Curry CJ, Chitayat D,Grebe T, et al. Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome. Genomics. Feb 2002;79(2):186-196.
    10. Osborne LR, Li M, Pober B, Chitayat D, Bodurtha J, Mandel A, Costa T, Grebe T, et al. A 1.5 million-base pair inversion polymorphism in families with Williams-Beuren syndrome.Nat Genet. Nov 2001;29(3):321-325.

    About Barrow

    Since our doors opened as a regional specialty center in 1962, we have grown into one of the premier destinations in the world for neurology and neurosurgery. Our experienced, highly skilled, and comprehensive team of neurological specialists can provide you with a complete spectrum of care–from diagnosis through outpatient neurorehabilitation–under one roof. Barrow Neurological Institute: Discover. Educate. Heal.