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  • Contact Dr. Ahmad

    Email [email protected]

    Specialties

    Saif Ahmad, PhD

    Assistant Professor
    Neurosurgery

    Saif Ahmad, PhD, is an assistant professor in the Department of Neurosurgery at Barrow Neurological Institute.

    Dr. Ahmad’s expertise includes molecular studies of neurodegenerative diseases. He is a member of the American Heart Association and Indian Academy of Neurosciences.

    Dr. Ahmad earned his doctorate in biotechnology from Hamdard University in New Delhi, India, and his Master of Science in organic chemistry from Mahatma Jyotiba Phule Rohilkhand University in Bareilly, Uttar Pradesh, India. He began his postdoctoral fellowship in the Program in Molecular Medicine at the University of Massachusetts Medical School in Worcester. The laboratory moved to Augusta University in Augusta, Georgia, where he completed his training.

    Dr. Ahmad’s current research focuses on the inflammatory mechanisms of stroke. He is particularly fascinated with the molecular mechanisms governing complement-mediated neurodegeneration, neurovascular dysfunction, and synapse elimination in stroke. He is also interested in vascular contributions to cognitive impairment and dementia.

    Education & Training
    • Research Scientist, Texas Tech University Health Sciences Center, 2015-2016
    • Associate Professor, King Abdulaziz University, 2012-2015
    • Postdoctoral Fellowship, University of Massachusetts Medical School and Augusta University 2007-2012
    • PhD, Jamia Hamdard (Hamdard University), New Delhi, Biotechnology, 2004
    • MSc, Mahatma Jyotiba Phule Rohilkhand University, Chemistry, 1998
    • BSc; Mahatma Jyotiba Phule Rohilkhand University; Botany, Zoology, & Chemistry, 1996
    Professional Memberships
    • American Heart Association
    • Indian Academy of Neuroscience
    Honors and Awards
    • Research Associate Fellowship, Ministry of Ayurveda, Yoga & Naturopathy, Unani, Siddha, and Homoeopathy; Ministry of Health and Family Welfare, Government of India, 2004-2005
    • Junior and Senior Research Fellowship, Technology Mission on Oilseeds and Pulses, Council of Scientific and Industrial Research, Ministry of Health and Family Welfare, Government of India, 2004
    • Senior Research Fellowship, Central Council for Research in Unani Medicine, Ministry of Health and Family Welfare, Government of India 2000-2002
    • Hamdard National Foundation Research Fellowship, Hamdard University, New Delhi, 2003-2004
    Selected Publications
    1. Ahmad S, Pandya C, Kindelin A, Bhatia K, Chaudhary R, Dwivedi AK, Eschbacher JM, Liu Q, Waters MF, Hoda MN, Ducruet AF. C3a receptor antagonist therapy is protective with or without thrombolysis in murine thromboembolic stroke. Br J Pharmacol. 2020;177(11):2466-2477.
    2. Kannan A, Jiang X, He L, Ahmad S, Gangwani L. ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy. Brain. 2020;143(1): 69-93.
    3. Ahmad S, Bhatia K, Kindelin A, Ducruet AF. The role of complement C3a receptor in stroke. Neuromolecular Med. 2019;21(4):467-473.
    4. Ahmad S, Kindelin A, Khan SA, Ahmed M, Hoda MN, Bhatia K, Ducruet AF. C3a receptor inhibition protects brain endothelial cells against oxygen-glucose deprivation/reperfusion. Exp Neurobiol. 2019;28(2):216-228.
    5. Ahmad S, Khan SA, Kindelin A, Mohseni T, Bhatia K, Hoda MN, Ducruet AF. Acetyl-11-Keto-Beta-Boswellic Acid (Akba) attenuates oxidative stress, inflammation, complement activation and cell death in brain endothelial cells following OGD/reperfusion. Neuromolecular Med. 2019;21(4):505-516.
    6. Zhao XJ, Larkin TM, Lauver MA, Ahmad S, Ducruet AF. Tissue plasminogen activator mediates deleterious complement cascade activation in stroke. PLoS One. 2017;12(7):e0180822.
    7. Genabai NK, Kannan A, Ahmad S, Jiang X, Bhatia K, Gangwani L. Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy. Sci Rep. 2017;7(1):8295.
    8. Ahmad S, Bhatia K, Kannan A, Gangwani L. Molecular mechanisms of neurodegeneration in spinal muscular atrophy. J Exp Neurosci. 2016;10:39-49.
    9. Genabai NK, Ahmad S, Zhang Z, Jiang X, Gabaldon CA, Gangwani L. Genetic inhibition of JNK3 ameliorates spinal muscular atrophy. Hum Mol Genet. 2015;24(24):6986-7004.
    10. Ahmad S, Wang Y, Shaik GM, Burghes AH, Gangwani L. The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy. Hum Mol Genet. 2012; 15;21(12):2745-58.

    About Barrow Neurological Institute
    Since our doors opened as a regional specialty center in 1962, we have grown into one of the premier destinations in the world for neurology and neurosurgery. Our experienced, highly skilled, and comprehensive team of neurological specialists can provide you with a complete spectrum of care–from diagnosis through outpatient neurorehabilitation–under one roof. Barrow Neurological Institute: Discover. Educate. Heal.