Barrow-ASU Center for Preclinical Imaging

1. D.R. Griffiths, L.M. Law, C.Young,  A. Fuentes, S. Truran, N. Karamanova, L.C.
   Bell, G. Turner, H. Emerson, R. Gonzales, P.D. Reaven, C.C. Quarles, R.Q.
   Migrino, J. Lifshitz, Chronic Cognitive and Cerebrovascular Function Following
   Diffuse Mild to Moderate Traumatic Brain Injury in Rats. Journal of Neurotrauma,
   2022, May 20, online ahead of print
2. K. Bhatia, A. Kindelin, M. Nadeem, M.B. Khan, J.X. Yin, A. Fuentes, G.H. Turner,
   M.C. Preul, A.S. Ahmad, E.J. Mufson, M.N. Hoda, M.F. Waters, S. Ahmad, A.F.
   Ducruet, Complement C3a receptor (C3aR) mediates vascular dysfunction,
   hippocampal pathology and cognitive impairment in a mouse model of VCID.
   Translational Stroke Research, 2022, Mar 8, online ahead of print
3. C. Han, M. Lang, C. Nguyen, E.L. Melendez, S. Mehta, G. Turner, M.T. Lawton,
   S.P. Oh, Novel Experimental Model of Brain Arteriovenous Malformations Using
   Conditional ALK1 Gene Deletion in Transgenic Mice. Journal of Neurosurgery,
   2021, Nov 5:1-21
4. V.N. Bharadwaj, C. Copeland, E. Mathew, J. Newbern, T.R. Anderson, J. Lifshitz,
   V.D. Kodibagkar, S.E. Stabenfeldt, Sex dependent macromolecule and
   nanoparticle delivery in experimental brain injury. Tissue Engineering, 2020, Jul,
   26(13-14):688-701
5. S. Agarwal, P.K. Gulaka, U. Rastogi, V.D. Kodibagkar, More bullets for PISTOL:
   linear and cyclic siloxane reporter probes for quantitative 1H MR oximetry, Sci
   Rep., 2020, 10(1):1399
6. Vidya Shankar R, Kodibagkar VD*. A Faster PISTOL for 1H MR-based
   Quantitative Tissue Oximetry. NMR Biomed 2019. 32(5):e4076. doi:
   10.1002/nbm.407. PMID: 30811753
7. Su F, Agarwal S, Pan T, Qiao Y, Zhang L, Shi Z, Kong X, Shi Z, Day K, Chen M,
   Meldrum D, Kodibagkar VD, Tian Y*, Multifunctional PHPMA-derived polymers
   for pH sensing, fluorescence imaging and magnetic resonance imaging. ACS
   Appl Mater Interfaces. 2018 Jan 17;10(2):1556-1565. doi:
   10.1021/acsami.7b15796
8. M. Chauhan ,  R.V. Shankar, N.A. Kumar, V.D. Kodibagkar, R. Sadleir, Multi-shot
   Echo-Planar MREIT for fast imaging of conductivity, current density and electric
   field distributions, Magnetic Resonance in Medicine, 2018, 79:71–82
9. E.M. Rutter, T.L. Stepien, B.J. Anderies, J.D. Placensia, E.C. Woolf, A.C.
   Scheck, G.H. Turner, Q. Liu, D. Frakes, V. Kodibagkar, Y. Kuang, M.C. Preul,
   E.J. Kostelich, Mathematical Analysis of Glioma Growth in a Murine Model,
   Scientifc Reports, 2017, May, 7(1):2508
10. N.L. Martirosyan, G.H. Turner, J.A. Kaufman, M.Y.S. Kalani, N. Theodore, M.C.
    Preul, Manganese Enhanced MRI Offers Correlation with Severity of Spinal Cord
    Injury of Experimental Models, The Open Neuroimaging Journal, The Open
    Neuroimaging Journal, 2016, Nov, 10(1):139-47
11. E.C. Woolf, K.L. Curley, Q. Liu, G.H. Turner, J.A. Charlton, M.C. Preul, A.C.
    Scheck, The ketogenic diet alters the hypoxic response and effects downstream
    processes involved in angiogenesis, invasion and vascular permeability in
    glioma, PLOS ONE, 2015, Jun, 10(6):e0130357
12. Addington C, Cusick A, Shankar RV, Agarwal S, Stabenfeldt SE, Kodibagkar VD, Siloxane nanoprobes for labeling and dual functional modality imaging of
    neural stem cells. Annals of Biomedical Engineering, 2015 44(3):816-827. PMID:
    26597417
13. J X. Yin, G.H. Turner, S.W. Coons, M. Maalouf, E.M. Reiman, J. Shi, Association
    of amyloid burden, brain atrophy and memory deficits in aged Apolipoprotein ε4
    Mice, Current Alzheimer Research, 2014, Mar, 11(3):283-90
14. J. Bell, Q.-W. Liu, Q. Zhao, Y. Gan, F.-D. Shi, G.H. Turner, Visualization of
    inflammation and demyelination in 2D2 transgenic mice with rodent MRI, J
    Neuroimmunol, 2013, Nov, 264(1-2):35-40
15. J.A. Kaufman, G.H. Turner, P.A. Holroyd, F. Rovero, A. Grossman, Brain Volume
    of the Newly-Discovered Species Rhynchocyon udzungwensis (Mammalia:
    Afrotheria: Macroscelidea): Implications for Encephalization in Sengis, PLOS
    ONE, 2013, 8(3):e58667
16. D.-Y. Kim, J. Hao, R. Liu, G.H. Turner, J.M. Rho, F.-D. Shi, Inflammation-
    Mediated Memory Dysfunction and Effects of Ketogenic Diet in a Murine Model
    of MS, PLOS ONE, 2012, 7(5): e35476
17. Q. Liu, Y. Cai, G.H. Turner, H. An, A Magnetic Resonance (MR) Compatible
    Selective Brain Temperature Manipulation System for Small Animal, Medical
    Devices: Evidence and Research, 2012, Mar, 2012(5):12-22
18. J.-X. Yin, G.H. Turner, H.-J, Lin, S.W. Coons, S.T. Marsh, J. Shi, Deficits in
    spatial learning and memory is associated with hippocampal volume loss in aged
    transgenic ApoE 4 mice, Journal of Alzheimer’s Disease, 2011, Nov, 27(1):89-98
19. J. Hao, A.R. Simard, G.H. Turner, J.Wu, P. Whiteaker, R.J. Lukas, F.-D. Shi,
    Attenuation of CNS Inflammatory responses by nicotine involves α-7 and non-α7
    nicotinic receptors, Experimental Neurology, 2011, Jan, 227(1):110-119

Meeting a Variety of Scanning Needs

The 7T MRI at the Center for Preclinical Imaging is equipped with a suite of imaging techniques that meet a variety of scanning needs. Some examples are as follows:

High-resolution Anatomy

The 7T has a variety of scans available for visualization of measurement of anatomy. High signal to noise and optimized protocols provide robust measurement in a variety of preclinical models.

Functional MRI

Over the last decade functional MRI (fMRI) has become the most popular method for mapping brain function. Preclinical MRI provides a platform for a investigating range of topics from how pharmacologic compounds affect brain function to the better understanding of the mechanisms behind fMRI itself.

Perfusion

Measurement of perfusion and contrast agent effects are a valuable tool for examining neuropathologies such as brain tumors and stroke. Contrast agent bolus tracking, relaxivity measurements, and perfusion measurements are some of the methods available to researchers using the Center.

Diffusion

The 7T has routines available for acquiring images weighted for local water diffusion. Such imaging is used for characterization of disease state, such as the hypoxic edema associated with vascular stroke. Diffusion tensor imaging uses restricted diffusion data to generate images of fiber tracks in the brain or spine.

Angiography

Visualization of the vasculature is important for the study of vascular disease, stenosis, and blood flow occlusion. High-resolution, in vivo vessel imaging is possible with the use of specialized imaging techniques and/or contrast agents.

Cardiac Function

Cardiac disease is the number one cause of death in the United States. The 7T MRI at the Center for Preclinical Imaging offers state-of-the-art methods for acquiring images of the cardiac cycle to allow in vivo analysis of preclinical cardiac disease models.

Bruker Biospec 7-Tesla MRI

This high-field magnetic resonance imaging (MRI) system has a 30-cm bore with a 200-mm gradient set (20 G/m) and a high-power 116-mm gradient insert (60 G/m). We have multiple acquisition coils to suit a variety of applications (brain, body, etc.) along with 31P and 13C coils for multinuclear spectroscopy.

The 7 Tesla (7T) MRI at the Center for Preclinical Imaging is equipped with a host of imaging capabilities to meet a variety of scanning needs:

• High-resolution anatomy. The 7T MRI has numerous scans available for visualization and measurement of anatomy. High signal-to-noise and optimized protocols allow precise measurement of anatomical structures with a spatial resolution of less than 100 microns.
• Functional MRI. Over the past decade, functional MRI (fMRI) has become the most popular method for mapping brain function. Our preclinical MRI is a platform for a range of investigations—from how pharmacologic compounds affect brain function to the quest to better understand the mechanisms underlying fMRI itself.
• Perfusion. The measurement of the effects of perfusion and contrast agents is a valuable tool for examining neuropathologies such as brain tumors and stroke. Contrast agent bolus tracking, relaxivity measurements, and perfusion measurements are some of the methods available to researchers using the Center.
• Diffusion. The 7T MRI has programmed routines for acquiring images weighted for local water diffusion. This feature can be used to characterize disease states such as hypoxic edema associated with vascular stroke. Diffusion tensor imaging uses restricted diffusion data to generate images of fiber tracts in the brain.
• Angiography. The visualization of vascular anatomy is important for the study of vascular disease, stenosis, and blood-flow occlusion. High-resolution in vivo imaging of vessels is possible with the use of specialized imaging techniques, contrast agents, or both.
• Cardiac Function. Cardiac disease is the number one cause of death in the United States. The 7T MRI at the Barrow-ASU Center for Preclinical Imaging offers cutting-edge methods for gathering images of the cardiac cycle for in vivo analysis of preclinical cardiac disease models.

Bruker Albira Si MicroPET

Positron Emission Tomography (PET) imaging is a nuclear medicine method used to observe metabolic processes in vivo. PET uses radioactive tracers that reflect cellular and metabolic processes in the body such as glucose uptake. This imaging method is used to examine a variety of pathologies including cancer, cardiac disease, inflammation, and neurodegenerative disease.

Bruker Skyscan MicroCT

Computed Tomography uses a series of X-ray images to generate renderings of cross sections of the body. It provides high-resolution images of both soft tissue and bone.  It is widely used to evaluate muscle and bone disorders and study pathologies including cardiac disease, tumors, and trauma.

Xenogen IVIS Spectrum®

The Spectrum system allows noninvasive longitudinal measurement of disease states, cell trafficking, and gene expression patterns. Both fluorescent and bioluminescent reporters can be imaged with this system as well as with 2- and 3-dimensional tomography.

Procedure Rooms

Two procedure rooms equipped with medical gasses, fume hoods, and basic laboratory equipment (e.g., scales, pipettes) are available for study preparation. Holding rooms are also available for a per diem fee (Contact Us).

Computing

A data analysis workstation is available for end users to work with their data offline. A file-transfer protocol (FTP) server also is available to facilitate remote access to study data and data transfer to an off-site location.