Barrow-ASU Center for Preclinical Imaging
Focus and Mission
The mission of the Barrow-ASU Center for Preclinical is to provide state-of-the-art imaging technology and expertise for researchers in the Phoenix area. Our center provides a wide array of imaging modalities including MRI, bioluminescence and florescence, microPET, and microCT.
The Center is a joint effort between Barrow Neurological Institute and Arizona State University. Together, our goal is to provide essential core technologies to Valley researchers and, as a result, advance biosciences across the entire State of Arizona.
Over the past several decades, advances in imaging science have unlocked new discoveries in biology and medicine. Our facility makes this advanced technology available to researchers across Central Arizona. Using these resources, investigators can examine the in vivo anatomy and function of their preclinical models.
In addition to advanced technology, the Center for Preclinical Imaging also offers professional expertise to help researchers develop and implement their imaging protocols.
Novel experimental model of brain arteriovenous malformations using conditional Alk1 gene deletion in transgenic mice
By Chul Han, Michael J Lang, Candice L Nguyen, Ernesto Luna Melendez, Shwetal Mehta, Gregory H Turner, Michael T Lawton, S Paul Oh
Published in Journal of Neurosurgery
Hereditary hemorrhagic telangiectasia is the only condition associated with multiple inherited brain arteriovenous malformations (AVMs). Therefore, a model was developed with a genetics-based approach that conditionally deleted the causative activin receptor-like kinase 1 (Acvrl1 or Alk1) gene. Radiographic and histopathological findings were correlated, and AVM stability and hemorrhagic behavior over time were examined.
Core Staff Members
Research Engineer II