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Sylvia Perez, PhD
Tau, Splicing, Dementia
Sylvia Perez, PhD, is an associate professor in the Department of Translational Neuroscience at Barrow Neurological Institute.
Dr. Perez’s expertise includes comparative neuroanatomy, with a focus on the biochemistry and connectivity of the cholinergic basal forebrain systems as well as on β-amyloid and tau pathology in Alzheimer’s disease, Down syndrome, and chronic traumatic encephalopathy. She is a member of the Society for Neuroscience.
Dr. Perez received her PhD in neuroanatomy from the University of Santiago de Compostela. She completed postdoctoral fellowships in neuroanatomy at the University of A Coruña and at the Consellería de Educación e Ciencias da Xunta de Galicia and in neurobiology at Rush University Medical Center.
Dr. Perez’s research interests include the neurobiology of the prodromal stage of Alzheimer’s disease and mild cognitive impairment. She also studies the role of tau in Down syndrome and dementia and the role of alpha-synuclein in the neurodegeneration of the cholinergic basal forebrain in Parkinson’s disease.
- Postdoctoral Fellowship, Rush University Medical Center, Department of Neurological Sciences, Neurobiology, 2002-2004
- Postdoctoral Fellowship, Rush University Medical Center, Department of Neurological Sciences, Neurobiology, 2000-2001
- Postdoctoral Fellowship, University of A Coruña, Neuroanatomy, 2000
- Postdoctoral Fellowship, Consellería de Educación e Ciencias da Xunta de Galicia, Neuroanatomy, 2000
- PhD, University of Santiago de Compostela, Neuroanatomy, 1998
- Predoctoral Fellowship, University of Santiago de Compostela, Neuroanatomy, 1995-1996
- Licentiate in Biology, University of Santiago de Compostela, Fundamental Biology, 1992
- Society for Neuroscience
- Arizona Alzheimer’s Disease Consortium at Barrow Neurological Institute Award, “Cortical tau pathologic signature: A biomarker for Down syndrome with and without dementia,” 2018-2019
- Arizona Alzheimer’s Disease Consortium at Barrow Neurological Institute Award, “Epigenetic dysregulation in cholinergic neurons in PD dementia,” 2016-2017
- Brinson Foundation Award, 2014-2015
- Rush University Research Council Pilot Award, 2009-2010
- Rush Department of Neurological Sciences Pilot Award, “Beta-amyloid induces cholinergic striatal dysfunction in a transgenic mouse model of Alzheimer’s disease.”
- Extraordinary Award for Doctoral Thesis, University of Santiago de Compostela, Biology Faculty, 1998
Naturally occurring histological findings and Alzheimer's-like pathology in the brain of aging African green monkeys (Chlorocebus sabaeus)
Date: 06/2023
Authors: Tatiana M. Corey, Oscar Illanes, Matthew Lawrence, Sylvia E. Perez, S E Pérez, Shervin Liddie, John J. Callanan
Ergonomic Analysis of Otologic Surgery: Comparison of Endoscope and Microscope
Date: 03/2023
Authors: Annie E. Arrighi-Allisan, Caleb J. Fan, Kevin Wong, Anni Wong, Katherine L. Garvey, Zachary G. Schwam, Peter Filip, Ameya A. Jategaonkar, Enrique Perez, George B. Wanna, Satish Govindaraj, Alfred-Marc Iloreta, Maura K. Cosetti
Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer's disease
Date: 03/2023
Authors: Laura J. Mahady, Sylvia E. Perez, Michael Malek-Ahmadi, Elliott J. Mufson
Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study
Date: 11/2022
Authors: Hannah Spitzer, Mathilde Ripart, Kirstie Whitaker, Felice D'Arco, Kshitij Mankad, Andrew A. Chen, Antonio Napolitano, Luca De Palma, Alessandro De Benedictis, Stephen Foldes, Stephen T. Foldes, Zachary Humphreys, Kai Zhang, Wenhan Hu, Jiajie Mo, Marcus Likeman, Shirin Davies, Christopher Güttler, Matteo Lenge, Nathan T. Cohen, Yingying Tang, Shan Wang, Aswin Chari, Martin Tisdall, Nuria Bargallo, Estefanía Conde-Blanco, Jose Carlos Pariente, Saül Pascual-Diaz, Ignacio Delgado-Martínez, Carmen Pérez-Enríquez, Ilaria Lagorio, Eugenio Abela, Nandini Mullatti
Primary prevention recommendations to reduce the risk of cognitive decline
Date: 08/2022
Authors: Marwan N. Sabbagh, Adriana Perez, Thomas M. Holland, Malaz Boustani, Stephanie R. Peabody, Kristine Yaffe, Michelle Bruno, Russell Paulsen, Kelly O'Brien, Naila Wahid, Rudolph E. Tanzi
Sylvia Perez, PhD
Tau, Splicing, Dementia
Sylvia Perez, PhD, is an associate professor in the Department of Translational Neuroscience at Barrow Neurological Institute.
Dr. Perez’s expertise includes comparative neuroanatomy, with a focus on the biochemistry and connectivity of the cholinergic basal forebrain systems as well as on β-amyloid and tau pathology in Alzheimer’s disease, Down syndrome, and chronic traumatic encephalopathy. She is a member of the Society for Neuroscience.
Dr. Perez received her PhD in neuroanatomy from the University of Santiago de Compostela. She completed postdoctoral fellowships in neuroanatomy at the University of A Coruña and at the Consellería de Educación e Ciencias da Xunta de Galicia and in neurobiology at Rush University Medical Center.
Dr. Perez’s research interests include the neurobiology of the prodromal stage of Alzheimer’s disease and mild cognitive impairment. She also studies the role of tau in Down syndrome and dementia and the role of alpha-synuclein in the neurodegeneration of the cholinergic basal forebrain in Parkinson’s disease.
- Postdoctoral Fellowship, Rush University Medical Center, Department of Neurological Sciences, Neurobiology, 2002-2004
- Postdoctoral Fellowship, Rush University Medical Center, Department of Neurological Sciences, Neurobiology, 2000-2001
- Postdoctoral Fellowship, University of A Coruña, Neuroanatomy, 2000
- Postdoctoral Fellowship, Consellería de Educación e Ciencias da Xunta de Galicia, Neuroanatomy, 2000
- PhD, University of Santiago de Compostela, Neuroanatomy, 1998
- Predoctoral Fellowship, University of Santiago de Compostela, Neuroanatomy, 1995-1996
- Licentiate in Biology, University of Santiago de Compostela, Fundamental Biology, 1992
- Society for Neuroscience
- Arizona Alzheimer’s Disease Consortium at Barrow Neurological Institute Award, “Cortical tau pathologic signature: A biomarker for Down syndrome with and without dementia,” 2018-2019
- Arizona Alzheimer’s Disease Consortium at Barrow Neurological Institute Award, “Epigenetic dysregulation in cholinergic neurons in PD dementia,” 2016-2017
- Brinson Foundation Award, 2014-2015
- Rush University Research Council Pilot Award, 2009-2010
- Rush Department of Neurological Sciences Pilot Award, “Beta-amyloid induces cholinergic striatal dysfunction in a transgenic mouse model of Alzheimer’s disease.”
- Extraordinary Award for Doctoral Thesis, University of Santiago de Compostela, Biology Faculty, 1998
Naturally occurring histological findings and Alzheimer's-like pathology in the brain of aging African green monkeys (Chlorocebus sabaeus)
Date: 06/2023
Authors: Tatiana M. Corey, Oscar Illanes, Matthew Lawrence, Sylvia E. Perez, S E Pérez, Shervin Liddie, John J. Callanan
Ergonomic Analysis of Otologic Surgery: Comparison of Endoscope and Microscope
Date: 03/2023
Authors: Annie E. Arrighi-Allisan, Caleb J. Fan, Kevin Wong, Anni Wong, Katherine L. Garvey, Zachary G. Schwam, Peter Filip, Ameya A. Jategaonkar, Enrique Perez, George B. Wanna, Satish Govindaraj, Alfred-Marc Iloreta, Maura K. Cosetti
Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer's disease
Date: 03/2023
Authors: Laura J. Mahady, Sylvia E. Perez, Michael Malek-Ahmadi, Elliott J. Mufson
Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study
Date: 11/2022
Authors: Hannah Spitzer, Mathilde Ripart, Kirstie Whitaker, Felice D'Arco, Kshitij Mankad, Andrew A. Chen, Antonio Napolitano, Luca De Palma, Alessandro De Benedictis, Stephen Foldes, Stephen T. Foldes, Zachary Humphreys, Kai Zhang, Wenhan Hu, Jiajie Mo, Marcus Likeman, Shirin Davies, Christopher Güttler, Matteo Lenge, Nathan T. Cohen, Yingying Tang, Shan Wang, Aswin Chari, Martin Tisdall, Nuria Bargallo, Estefanía Conde-Blanco, Jose Carlos Pariente, Saül Pascual-Diaz, Ignacio Delgado-Martínez, Carmen Pérez-Enríquez, Ilaria Lagorio, Eugenio Abela, Nandini Mullatti
Primary prevention recommendations to reduce the risk of cognitive decline
Date: 08/2022
Authors: Marwan N. Sabbagh, Adriana Perez, Thomas M. Holland, Malaz Boustani, Stephanie R. Peabody, Kristine Yaffe, Michelle Bruno, Russell Paulsen, Kelly O'Brien, Naila Wahid, Rudolph E. Tanzi