The ABATE Study

Purpose

The ABATE Study is testing an investigational vaccine for Alzheimer’s disease in people with Down Syndrome. We want to see if the vaccine is safe. We also want to see if it slows the progression of Alzheimer’s disease in people with Down syndrome.

The study treatment, ACI-24.060, is a new vaccine which is not yet on the market. It may help to remove amyloid in the brain. This could slow down memory loss and thinking problems.

Who can participate

You may be able to join this study if you:

• Have Down syndrome
• Be between 35 and 50 years old
• Have a study partner
  • Your study partner is someone who could support you during your participation. For example, they could be a family member or any relative close to you, or a caregiver.

Visits

The study lasts for about two years and is split into three parts:

• Screening period
• Treatment period
• Follow-up period