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Fredric Manfredsson, PhD
Gene Therapy, Parkinson's
Fredric Manfredsson, PhD, is a professor in the Department of Translational Neuroscience at Barrow Neurological Institute.
Dr. Manfredsson’s expertise includes microbiology and virology, with a special interest in gene therapy for Parkinson’s disease and other neurodegenerative diseases. He is a member of the American Society for Gene & Cell Therapy, The American Society for Neural Therapy and Repair, and the Society for Neuroscience.
Dr. Manfredsson earned his doctorate degree in neuroscience from the University of Florida in Gainesville, where he also completed a postdoctoral fellowship in neuroscience.
Dr. Manfredsson’s research has multiple focuses. One aspect is to better understand the role of the protein alpha-synuclein in both healthy cells and those affected by Parkinson’s disease. His research also emphasizes understanding the symptomology of the disease, with a focus on the treatment of levodopa-induced dyskinesia and nonmotor symptoms experienced by nearly all patients with Parkinson’s disease.
- Postdoctoral Fellowship, University of Florida, Department of Neuroscience, 2006-2010
- PhD, University of Florida, Graduate Program in Biomedical Sciences, Neuroscience, 2006
- BS, Arizona State University, Microbiology, 1999
- President, American Society for Neural Therapy and Repair, 2018-2020
- Fellow, American Society for Neural Therapy and Repair, 2015-Present
- Cover Image, Molecular Therapy, June 2009, March 2015
- Julius Axelrod Travel Award, Society for Neuroscience, 2011
- Alumni Fellowship, University of Florida, 2001-2005
- American Society for Gene & Cell Therapy
- The American Society for Neural Therapy and Repair
- Society for Neuroscience
Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy.
Date: 06/2024
Authors: Nicole J Corbin-Stein, Gabrielle M Childers, Jhodi M Webster, Asta Zane, Ya-Ting Yang, Md Akkas Ali, Ivette M Sandoval, Fredric P. Manfredsson, Jeffrey H Kordower, Daniel J Tyrrell, Ashley S Harms
"Advanced" Parkinson's disease: A review.
Date: 06/2024
Authors: Sana Aslam, Fredric P. Manfredsson, Ashley Stokes, Holly Shill
ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO.
Date: 03/2024
Authors: Diptaman Chatterjee, Lianna Y D'Brant, Benjamin M Hiller, David J Marmion, Ivette M Sandoval, Kelvin C Luk, Fredric P Manfredsson, Anne Messer, Jeffrey H Kordower, David C Butler
Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy.
Date: 03/2024
Authors: Valerie Joers, Benjamin C Murray, Caroline McLaughlin, Danielle Oliver, Hannah Staley, Jazmyn Coronado, Cindy Achat-Mendes, Sanam Golshani, Sean D Kelly, Matthew Goodson, Danica Lee, Fredric P. Manfredsson, Bob M Moore, Malú Gámez Tansey
IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy.
Date: 01/2024
Authors: Nicole J Corbin-Stein, Gabrielle M Childers, Jhodi M Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Rajesh Gupta, Fredric P. Manfredsson, Jeffrey H Kordower, Ashley S Harms
Fredric Manfredsson, PhD
Gene Therapy, Parkinson's
Fredric Manfredsson, PhD, is a professor in the Department of Translational Neuroscience at Barrow Neurological Institute.
Dr. Manfredsson’s expertise includes microbiology and virology, with a special interest in gene therapy for Parkinson’s disease and other neurodegenerative diseases. He is a member of the American Society for Gene & Cell Therapy, The American Society for Neural Therapy and Repair, and the Society for Neuroscience.
Dr. Manfredsson earned his doctorate degree in neuroscience from the University of Florida in Gainesville, where he also completed a postdoctoral fellowship in neuroscience.
Dr. Manfredsson’s research has multiple focuses. One aspect is to better understand the role of the protein alpha-synuclein in both healthy cells and those affected by Parkinson’s disease. His research also emphasizes understanding the symptomology of the disease, with a focus on the treatment of levodopa-induced dyskinesia and nonmotor symptoms experienced by nearly all patients with Parkinson’s disease.
- Postdoctoral Fellowship, University of Florida, Department of Neuroscience, 2006-2010
- PhD, University of Florida, Graduate Program in Biomedical Sciences, Neuroscience, 2006
- BS, Arizona State University, Microbiology, 1999
- President, American Society for Neural Therapy and Repair, 2018-2020
- Fellow, American Society for Neural Therapy and Repair, 2015-Present
- Cover Image, Molecular Therapy, June 2009, March 2015
- Julius Axelrod Travel Award, Society for Neuroscience, 2011
- Alumni Fellowship, University of Florida, 2001-2005
- American Society for Gene & Cell Therapy
- The American Society for Neural Therapy and Repair
- Society for Neuroscience
Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy.
Date: 06/2024
Authors: Nicole J Corbin-Stein, Gabrielle M Childers, Jhodi M Webster, Asta Zane, Ya-Ting Yang, Md Akkas Ali, Ivette M Sandoval, Fredric P. Manfredsson, Jeffrey H Kordower, Daniel J Tyrrell, Ashley S Harms
"Advanced" Parkinson's disease: A review.
Date: 06/2024
Authors: Sana Aslam, Fredric P. Manfredsson, Ashley Stokes, Holly Shill
ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO.
Date: 03/2024
Authors: Diptaman Chatterjee, Lianna Y D'Brant, Benjamin M Hiller, David J Marmion, Ivette M Sandoval, Kelvin C Luk, Fredric P Manfredsson, Anne Messer, Jeffrey H Kordower, David C Butler
Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy.
Date: 03/2024
Authors: Valerie Joers, Benjamin C Murray, Caroline McLaughlin, Danielle Oliver, Hannah Staley, Jazmyn Coronado, Cindy Achat-Mendes, Sanam Golshani, Sean D Kelly, Matthew Goodson, Danica Lee, Fredric P. Manfredsson, Bob M Moore, Malú Gámez Tansey
IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy.
Date: 01/2024
Authors: Nicole J Corbin-Stein, Gabrielle M Childers, Jhodi M Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Rajesh Gupta, Fredric P. Manfredsson, Jeffrey H Kordower, Ashley S Harms