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Fredric Manfredsson, PhD
Fredric Manfredsson, PhD, is an associate professor in the Department of Translational Neuroscience at Barrow Neurological Institute.
Dr. Manfredsson’s expertise includes microbiology and virology, with a special interest in gene therapy for Parkinson’s disease and other neurodegenerative diseases. He is a member of the American Society for Gene & Cell Therapy, The American Society for Neural Therapy and Repair, and the Society for Neuroscience.
Dr. Manfredsson earned his doctorate degree in neuroscience from the University of Florida in Gainesville, where he also completed a postdoctoral fellowship in neuroscience.
Dr. Manfredsson’s research has multiple focuses. One aspect is to better understand the role of the protein alpha-synuclein in both healthy cells and those affected by Parkinson’s disease. His research also emphasizes understanding the symptomology of the disease, with a focus on the treatment of levodopa-induced dyskinesia and nonmotor symptoms experienced by nearly all patients with Parkinson’s disease.
- Postdoctoral Fellowship, University of Florida, Department of Neuroscience, 2006-2010
- PhD, University of Florida, Graduate Program in Biomedical Sciences, Neuroscience, 2006
- BS, Arizona State University, Microbiology, 1999
- President, American Society for Neural Therapy and Repair, 2018-2020
- Fellow, American Society for Neural Therapy and Repair, 2015-Present
- Cover Image, Molecular Therapy, June 2009, March 2015
- Julius Axelrod Travel Award, Society for Neuroscience, 2011
- Alumni Fellowship, University of Florida, 2001-2005
- American Society for Gene & Cell Therapy
- The American Society for Neural Therapy and Repair
- Society for Neuroscience
Gene therapy for Parkinson's disease-Ample room for optimism
Date: 12/2025
Authors: Ivette M. Sandoval, Michael F. Salvatore, Fredric P. Manfredsson
Tau, amyloid-β and α-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology
Date: 11/2025
Authors: Jhodi M. Webster, Ya-Ting Yang, Aidan T. Miller, Asta Zane, Kasandra Scholz, William J. Stone, Nikhita Mudium, Nicole J. Corbin-Stein, Woong-Jai Won, Anna C. Stoll, Kelsey M. Greathouse, Noelle H. Cooper, Lillian F. Long, Phaedra N. Manuel, Jeremy H. Herskowitz, Talene A. Yacoubian, Daniel J. Tyrrell, Ivette M. Sandoval, Fredric P. Manfredsson, Jeffrey H. Kordower, Ashley S. Harms
Disease-modifying, multidimensional efficacy of putaminal Ca1.3-shRNA gene therapy in aged parkinsonism male and female macaques
Date: 09/2025
Authors: Kathy Steece-Collier, Margaret E. Caulfield, Molly J. Vander Werp, Scott J. Muller, Jennifer A. Stancati, Yaping Chu, Ivette M. Sandoval, Timothy J. Collier, Jeffrey H. Kordower, Fredric P. Manfredsson
Physics of Protein Aggregation in Normal and Accelerated Brain Aging
Date: 08/2025
Authors: Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson
Effects of genetic knockdown of the serotonin transporter on established L-DOPA-induced dyskinesia and gene expression in hemiparkinsonian rats
Date: 03/2025
Authors: Grace McManus, Ashley Galfano, Carla Budrow, Natalie Lipari, Kuei Y. Tseng, Fredric P. Manfredsson, Christopher Bishop
Phoenix, AZ 85013
Fredric Manfredsson, PhD
Fredric Manfredsson, PhD, is an associate professor in the Department of Translational Neuroscience at Barrow Neurological Institute.
Dr. Manfredsson’s expertise includes microbiology and virology, with a special interest in gene therapy for Parkinson’s disease and other neurodegenerative diseases. He is a member of the American Society for Gene & Cell Therapy, The American Society for Neural Therapy and Repair, and the Society for Neuroscience.
Dr. Manfredsson earned his doctorate degree in neuroscience from the University of Florida in Gainesville, where he also completed a postdoctoral fellowship in neuroscience.
Dr. Manfredsson’s research has multiple focuses. One aspect is to better understand the role of the protein alpha-synuclein in both healthy cells and those affected by Parkinson’s disease. His research also emphasizes understanding the symptomology of the disease, with a focus on the treatment of levodopa-induced dyskinesia and nonmotor symptoms experienced by nearly all patients with Parkinson’s disease.
Phoenix, AZ 85013
- Postdoctoral Fellowship, University of Florida, Department of Neuroscience, 2006-2010
- PhD, University of Florida, Graduate Program in Biomedical Sciences, Neuroscience, 2006
- BS, Arizona State University, Microbiology, 1999
- President, American Society for Neural Therapy and Repair, 2018-2020
- Fellow, American Society for Neural Therapy and Repair, 2015-Present
- Cover Image, Molecular Therapy, June 2009, March 2015
- Julius Axelrod Travel Award, Society for Neuroscience, 2011
- Alumni Fellowship, University of Florida, 2001-2005
- American Society for Gene & Cell Therapy
- The American Society for Neural Therapy and Repair
- Society for Neuroscience
Gene therapy for Parkinson's disease-Ample room for optimism
Date: 12/2025
Authors: Ivette M. Sandoval, Michael F. Salvatore, Fredric P. Manfredsson
Tau, amyloid-β and α-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology
Date: 11/2025
Authors: Jhodi M. Webster, Ya-Ting Yang, Aidan T. Miller, Asta Zane, Kasandra Scholz, William J. Stone, Nikhita Mudium, Nicole J. Corbin-Stein, Woong-Jai Won, Anna C. Stoll, Kelsey M. Greathouse, Noelle H. Cooper, Lillian F. Long, Phaedra N. Manuel, Jeremy H. Herskowitz, Talene A. Yacoubian, Daniel J. Tyrrell, Ivette M. Sandoval, Fredric P. Manfredsson, Jeffrey H. Kordower, Ashley S. Harms
Disease-modifying, multidimensional efficacy of putaminal Ca1.3-shRNA gene therapy in aged parkinsonism male and female macaques
Date: 09/2025
Authors: Kathy Steece-Collier, Margaret E. Caulfield, Molly J. Vander Werp, Scott J. Muller, Jennifer A. Stancati, Yaping Chu, Ivette M. Sandoval, Timothy J. Collier, Jeffrey H. Kordower, Fredric P. Manfredsson
Physics of Protein Aggregation in Normal and Accelerated Brain Aging
Date: 08/2025
Authors: Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson
Effects of genetic knockdown of the serotonin transporter on established L-DOPA-induced dyskinesia and gene expression in hemiparkinsonian rats
Date: 03/2025
Authors: Grace McManus, Ashley Galfano, Carla Budrow, Natalie Lipari, Kuei Y. Tseng, Fredric P. Manfredsson, Christopher Bishop