canyon landscape

glioma

A Phase 0 /II Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection

In the proposed trial, patients will be administered ribociclib+everolimus prior to surgical resection of their tumor. Recurrent GBM patients will be randomized into one of the three time-interval...

Study of Sonodynamic Therapy in Participants With Recurrent High-Grade Glioma

A Phase 0 single center, first in human, open-label study of ascending energy doses of sonodynamic therapy (SDT) utilizing the MRgFUS combined with intravenous ALA to assess safety and...

Infigratinib in Recurrent High-Grade Glioma Patients

This trial is an open-label, multicenter, Phase 0 trial that will enroll up to 20 participants with recurrent high-grade glioma with FGFR1 K656E or FGFR3 K650E mutation or...

The Barrow 5-ALA Intraoperative Confocal (BALANCE) Study

This study will look at how well 5-ALA, an amino acid compound, can identify cancer cells during surgery and improve tumor removal in patients with high- and low-grade...