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  • Portrait of Jinglu Ai

    Contact Dr. Ai

    Call (602) 406-5404 or email [email protected]

    Jinglu Ai, MD, PhD

    Associate Professor,
    Neurobiology (602) 406-5404

    Jinglu Ai, MD, PhD, is an associate professor of neurobiology in the Barrow Aneurysm and AVM Research Center.

    Dr. Ai’s expertise includes translational research of neurological disorders, including traumatic brain injury and subarachnoid hemorrhage. He is a member of the Stroke Council of the American Heart Association/American Stroke Association and the World Stroke Organization.

    Dr. Ai earned both his master’s degree and medical degree from Heilongjiang University of Chinese Medicine and Pharmacy in Harbin, China. He earned a PhD in pathology from the Academy of Chinese Medical Science in Beijing and a PhD in neuroscience from the Roskilde University Center in Denmark. He completed postdoctoral fellowships in neuroscience at Stony Brook University in New York and The Hospital for Sick Children affiliated with the University of Toronto in Canada.

    Dr. Ai’s current research interests include translational mechanistic studies on the formation and rupture of aneurysms.

    Education & Training
    • Postdoctoral Fellow, University of Toronto, Program of Brain and Behavioral Sciences, Department of Neurology, The Hospital for Sick Children, Neuroscience, 2000-2001
    • Postdoctoral Fellow, Stony Brook University, Department of Psychiatry and Behavioral Sciences, Research Laboratory of Neuropsychopharmacology, Neuroscience, 1999-2000
    • PhD, Roskilde University Center, Department of Molecular Biology and Biochemistry, Neuroscience, 1999
    • Visiting Research Scientist, University of Copenhagen, Sankt Hans Hospital, Department of Biochemistry and Psychopharmacology, Neuroscience, 1995-1999
    • PhD, Academy of Chinese Medical Science, Department of Pathology, Central Research Laboratory, 1994
    • MSc, Heilongjiang University of Chinese Medicine and Pharmacy, School of Medicine, Medicine, 1991
    • MD, Heilongjiang University of Chinese Medicine and Pharmacy, School of Medicine, 1988
    Professional Memberships
    • Stroke Council, American Heart Association/American Stroke Association
    • World Stroke Organization
    Honors and Awards
    • Running Against Ruptures — Bob Wood Chair of Research and Donald Sutherland Chair of Research, The Brain Aneurysm Foundation, 2018
    • Cami Clark Chair of Research and Debbie Feiger Chair of Research, The Brain Aneurysm Foundation, 2016
    • Christopher C. Getch Chair of Research, The Brain Aneurysm Foundation, 2012
    • North Shore University Hospital, Brain Aneurysm Center Chair of Research, The Brain Aneurysm Foundation, 2011
    • He Shixi’s Prize for Best PhD Thesis, Academy of Chinese Medical Science, 1994
    Selected Publications
    1. Wan H, Wang Y, Ai J, Brathwaite S, Ni H, Macdonald RL, Hol EM, Meijers JCM, Vergouwen MDI. Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage. J Thromb Haemost. 2018;16(7):1413-1422.
    2. D’Abbondanza JA, Ai J, Lass E, Wan H, Brathwaite S, Tso MK, Lee C, Marsden PA, Macdonald RL. Robust effects of genetic background on responses to subarachnoid hemorrhage in mice. J Cereb Blood Flow Metab. 2016;36(11):1942-1954
    3. Yagi K, Lidington D, Wan H, Fares JC, Meissner A, Sumiyoshi M, Ai J, Foltz WD, Nedospasov SA, Offermanns S, Nagahiro S, Macdonald RL, Bolz SS. Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage. Stroke. 2015;46(8):2260-70.
    4. Lakovic K, Ai J, D’Abbondanza J, Tariq A, Sabri M, Alarfaj AK, Vasdev P, Macdonald RL. Bilirubin and its oxidation products damage brain white matter. J Cereb Blood Flow Metab. 2014;34(11):1837-47.
    5. Han SM, Wan H, Kudo G, Foltz WD, Vines DC, Green DE, Zoerle T, Tariq A, Brathwaite S, D’Abbondanza J, Ai J, Macdonald RL. Molecular alterations in the hippocampus after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2014;34(1):108-17.
    6. Sabri M, Ai J, Lass E, D’abbondanza J, Macdonald RL. Genetic elimination of eNOS reduces secondary complications of experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2013;33(7):1008-14.
    7. Sabri M, Ai J and Macdonald RL. Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan. Stroke, 2011;42 (5): 1454-1460.
    8. Sabri M, Ai J, Knight B, Tariq A, Jeon H, Shang X, Marsden PA, and Macdonald RL. Uncoupling of endothelial nitric oxide synthase after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2011;31(1):190-9.
    9. Bell JD, Park E, Ai J and Baker AJ. PICK1-mediated GluR2 Endocytosis Contributes to Cellular Injury After Neuronal Trauma. Cell Death and Differentiation, 2009;16:1665-80.
    10. Bell JD, Ai J, Chen Y, Baker AJ. Mild in vitro trauma induces rapid Glur2 endocytosis, robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells. Brain 2007;130:2528-2542
    11. Ai J, Liu E, Wang J, Chen Y, Yu J, Baker AJ. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J Neurotrauma 2007;24:960-978.

    About Barrow Neurological Institute
    Since our doors opened as a regional specialty center in 1962, we have grown into one of the premier destinations in the world for neurology and neurosurgery. Our experienced, highly skilled, and comprehensive team of neurological specialists can provide you with a complete spectrum of care–from diagnosis through outpatient neurorehabilitation–under one roof. Barrow Neurological Institute: Discover. Educate. Heal.