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    Tomoki Hashimoto, MD

    Professor, Neuro-anesthesiology and Neurobiology

    Tomoki Hashimoto, MD, is a professor of neuro-anesthesiology and neurobiology and the director of translational neurovascular research in the Barrow Aneurysm and AVM Research Center. He is board certified in anesthesiology by the American Board of Anesthesiology.

    Dr. Hashimoto’s expertise includes clinical anesthesiology and vascular biology. He earned his medical degree from Gifu University School of Medicine in Japan. He received his residency training in anesthesia at Gifu University Hospital, Thomas Jefferson University Hospital in Philadelphia, and NewYork-Presbyterian/Columbia University Medical Center. He completed a clinical fellowship at NewYork-Presbyterian/Columbia Medical Center and a research fellowship at the University of California-San Francisco, both in neuro-anesthesia.

    Dr. Hashimoto leads a program that focuses on the translational research of cerebrovascular diseases. His group studies the roles of inflammation and vascular remodeling in the pathophysiology of intracranial aneurysms and brain arteriovenous malformations. They are developing pharmacological therapies for the prevention of stroke caused by rupture of intracranial aneurysms and brain arteriovenous malformations.

    Education & Training
    • Research Fellow, University of California-San Francisco, Neuro-anesthesia, 2000-2001
    • Fellow, NewYork-Presbyterian/Columbia Medical Center, Neuro-anesthesia, 1999-2000
    • Resident, NewYork-Presbyterian/Columbia Medical Center, Anesthesia, 1997-1999
    • Resident, Thomas Jefferson University Hospital, Anesthesia, 1996-1997
    • Internship, Chestnut Hill Hospital, 1995-1996
    • Resident, Gifu University Hospital, Anesthesia, 1992-1995
    • MD, Gifu University, School of Medicine, 1992
    Professional Memberships
    • American Heart Association
    • American Society of Anesthesiologists
    • Association of University Anesthesiologists
    Honors and Awards
    • Fellow of the American Heart Association, 2013
    • Pfizer Health Care Research Scholarship, 1997
    • Noguchi Medical Research Institute Scholarship for U.S.A. Visiting Program, 1994
    • Noguchi Medical Research Institute Scholarship for U.S.A. Short Visiting Program, 1993
    Selected Publications
    1. Kotoda M, Furukawa H, Miyamoto T, Korai M, Shikata F, Kuwabara A, Xiong X, Rutledge C, Giffard RG, Hashimoto T. Role of myeloid lineage cell autophagy in ischemic brain injury. Stroke. 2018;49(6):1488-1495.
    2. Kuwabara A, Liu J, Kamio Y, Liu A, Lawton MT, Lee JW, Hashimoto T. Protective effect of mesenchymal stem cells against the development of intracranial aneurysm rupture in mice. Neurosurgery. 2017;81(6):1021-1028.
    3. Shimada K, Furukawa H, Wada K, Korai M, Wei Y, Tada Y, Kuwabara A, Shikata F, Kitazato KT, Nagahiro S, Lawton MT, Hashimoto T. Protective role of peroxisome proliferator-activated receptor-gamma in the development of intracranial aneurysm rupture. Stroke. 2015;46(6):1664-1672.
    4. Tada Y, Wada K, Shimada K, Makino H, Liang EI, Murakami S, Kudo M, Shikata F, Pena Silva RA, Kitazato KT, Hasan DM, Kanematsu Y, Nagahiro S, Hashimoto T. Estrogen protects against intracranial aneurysm rupture in ovariectomized mice. Hypertension. 2014;63(6):1339-1344.
    5. Makino H, Tada Y, Wada K, Liang EI, Chang M, Mobashery S, Kanematsu Y, Kurihara C, Palova E, Kanematsu M, Kitazato K, Hashimoto T. Pharmacological stabilization of intracranial aneurysms in mice: a feasibility study. Stroke. 2012;43(9):2450-2456.
    6. Kanematsu Y, Kanematsu M, Kurihara C, Tada Y, Tsou TL, van Rooijen N, Lawton MT, Young WL, Liang EI, Nuki Y, Hashimoto T. Critical roles of macrophages in the formation of intracranial aneurysm. Stroke. 2011;42(1):173-178.
    7. Nuki Y, Tsou TL, Kurihara C, Kanematsu M, Kanematsu Y, Hashimoto T. Elastase-induced intracranial aneurysms in hypertensive mice. Hypertension. 2009;54(6):1337-1344.
    8. Lawton MT, Stewart CL, Wulfstat AA, Derugin N, Hashimoto T, Young WL. The transgenic arteriovenous fistula in the rat: an experimental model of gene therapy for brain arteriovenous malformations. Neurosurgery. 2004;54(6):1463-1471; discussion 1471.
    9. Hashimoto T, Wen G, Lawton MT, Boudreau NJ, Bollen AW, Yang GY, Barbaro NM, Higashida RT, Dowd CF, Halbach VV, Young WL, University of California SFBSG. Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations. Stroke. 2003;34(4):925-931.
    10. Hashimoto T, Young WL, Aagaard BD, Joshi S, Ostapkovich ND, Pile-Spellman J. Adenosine-induced ventricular asystole to induce transient profound systemic hypotension in patients undergoing endovascular therapy. Dose-response characteristics. Anesthesiology. 2000;93(4):998-1001.

    View a complete list of publications on PubMed.

    About Barrow Neurological Institute

    Since our doors opened as a regional specialty center in 1962, we have grown into one of the premier destinations in the world for neurology and neurosurgery. Our experienced, highly skilled, and comprehensive team of neurological specialists can provide you with a complete spectrum of care–from diagnosis through outpatient neurorehabilitation–under one roof. Barrow Neurological Institute: Discover. Educate. Heal.