Bilateral Inferior Petrosal Sinus Sampling (BIPSS)

A pilot study examining the effects of pre-treatment with Korlym before performing bilateral inferior petrosal sinus sampling in patients with Cushing syndrome.

Purpose

This study will assess if by increasing ACTH and cortisol levels by virtue of antagonizing the glucocorticoid receptors with Korlym which will improve the diagnostic sensitivity of BIPSS. Korlym is a competitive glucocorticoid antagonist approved by the United States in 2012 for the treatment of Cushing syndrome in patients with concurrent hyperglycemia.