SBS 001

Blinded comparison of different alpha-synuclein seeding assays as cutaneous biomarkers of Lewy body dementias. Beach-NIH/R01 (NS118669-01).

Purpose

The purpose of this research is to determine the ability of skin biopsy analysis to predict a diagnosis of Lewy body dementia, and to determine whether the results of the skin biopsy analyses change over time. Lewy body dementias include Parkinson’s disease with dementia as well as dementia with Lewy bodies.

Who Can Participate

Patients with dementia with Lewy bodies, Parkinson’s disease without dementia (PD), and Parkinson’s disease with dementia (PDD), to assess the relative diagnostic sensitivity and specificity of immunohistochemistry.

Main Inclusion Criteria- Males or females ≥ 40 years of age; willingness to undergo the required clinical assessments and biopsies.