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Nadine Bakkar, PhD, is an assistant professor in the Department of Translational Neuroscience at Barrow Neurological Institute.
Dr. Bakkar received her doctorate from The Ohio State University in molecular biology in the laboratory of Dr. Denis Guttridge, focusing on NF-kappaB signaling pathways involved in muscle development and regeneration. She completed two postdoctoral fellowships, one at The Ohio State University Comprehensive Cancer Center and one at Barrow Neurological Institute as part of Dr. Robert Bowser’s laboratory.
Dr. Bakkar’s research interests include neurodegenerative diseases specifically amyotrophic lateral sclerosis (ALS), focusing on blood brain and blood-CSF barriers disruptions, as well as changes in RNA metabolism and transport that contribute to ALS pathogenesis.
Dr. Bakkar is a member of the Society of Neuroscience (SFN).
- Postdoctoral Fellowship, Barrow Neurological Institute, 2012-2015
- Postdoctoral Fellowship, The Ohio State University Comprehensive Cancer Center, 2008-2012
- PhD, The Ohio State University, Molecular Biology, 2008
- MS, American University of Beirut, Biology, Beirut, Lebanon, 2001
- BS, American University of Beirut, Biology, 1999
Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus
Date: 02/2023
Authors: Maria Čarna, Isaac G. Onyango, Stanislav Katina, Dušan Holub, Jan Sebastian Novotny, Marketa Nezvedova, Durga Jha, Zuzana Nedelska, Valentina Lacovich, Thijs Vande Vyvere, Ruben Houbrechts, Krystine Garcia-Mansfield, Ritin Sharma, Victoria David-Dirgo, Martin Vyhnalek, Kateřina Texlova, Hernan Chaves, Nadine Bakkar, Lucia Pertierra, Mojmir Vinkler, Hana Markova, Jan Laczo, Kateřina Sheardova, Marcela Hortova-Kohoutkova, Jan Frič, Giancarlo Forte, Petr Kaňovsky, Silvie Belaškova, Jiři Damborsky, Jakub Hort, Nicholas T. Seyfried, Robert Bowser
Longitudinal evaluation of myofiber microstructural changes in a preclinical ALS model using the transverse relaxivity at tracer equilibrium (TRATE): A preliminary study
Date: 01/2022
Authors: Laura C. Bell, Alberto E. Fuentes, Deborah R. Healey, Debbie R. Healey, Renee Chao, Nadine Bakkar, Rachael W. Sirianni, David X. Medina, Robert P. Bowser, Robert Bowser, Shafeeq S. Ladha, Natenael B. Semmineh, Ashley M. Stokes, C. Chad Quarles
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components
Date: 05/2021
Authors: Evan Lester, Felicia K. Ooi, Nadine Bakkar, Jacob Ayers, Amanda L. Woerman, Joshua Wheeler, Robert Bowser, George A. Carlson, Stanley B. Prusiner, Roy Parker
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease
Date: 02/2021
Authors: Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser
Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis
Date: 06/2020
Authors: J. Saul, E. Hutchins, R Reiman, M Saul, L W. Ostrow, B T. Harris, K Van Keuren-Jensen, R Bowser, Robert Bowser, N Bakkar, Nadine Bakkar
- English
Nadine Bakkar, PhD, is an assistant professor in the Department of Translational Neuroscience at Barrow Neurological Institute.
Dr. Bakkar received her doctorate from The Ohio State University in molecular biology in the laboratory of Dr. Denis Guttridge, focusing on NF-kappaB signaling pathways involved in muscle development and regeneration. She completed two postdoctoral fellowships, one at The Ohio State University Comprehensive Cancer Center and one at Barrow Neurological Institute as part of Dr. Robert Bowser’s laboratory.
Dr. Bakkar’s research interests include neurodegenerative diseases specifically amyotrophic lateral sclerosis (ALS), focusing on blood brain and blood-CSF barriers disruptions, as well as changes in RNA metabolism and transport that contribute to ALS pathogenesis.
Dr. Bakkar is a member of the Society of Neuroscience (SFN).
- Postdoctoral Fellowship, Barrow Neurological Institute, 2012-2015
- Postdoctoral Fellowship, The Ohio State University Comprehensive Cancer Center, 2008-2012
- PhD, The Ohio State University, Molecular Biology, 2008
- MS, American University of Beirut, Biology, Beirut, Lebanon, 2001
- BS, American University of Beirut, Biology, 1999
Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus
Date: 02/2023
Authors: Maria Čarna, Isaac G. Onyango, Stanislav Katina, Dušan Holub, Jan Sebastian Novotny, Marketa Nezvedova, Durga Jha, Zuzana Nedelska, Valentina Lacovich, Thijs Vande Vyvere, Ruben Houbrechts, Krystine Garcia-Mansfield, Ritin Sharma, Victoria David-Dirgo, Martin Vyhnalek, Kateřina Texlova, Hernan Chaves, Nadine Bakkar, Lucia Pertierra, Mojmir Vinkler, Hana Markova, Jan Laczo, Kateřina Sheardova, Marcela Hortova-Kohoutkova, Jan Frič, Giancarlo Forte, Petr Kaňovsky, Silvie Belaškova, Jiři Damborsky, Jakub Hort, Nicholas T. Seyfried, Robert Bowser
Longitudinal evaluation of myofiber microstructural changes in a preclinical ALS model using the transverse relaxivity at tracer equilibrium (TRATE): A preliminary study
Date: 01/2022
Authors: Laura C. Bell, Alberto E. Fuentes, Deborah R. Healey, Debbie R. Healey, Renee Chao, Nadine Bakkar, Rachael W. Sirianni, David X. Medina, Robert P. Bowser, Robert Bowser, Shafeeq S. Ladha, Natenael B. Semmineh, Ashley M. Stokes, C. Chad Quarles
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components
Date: 05/2021
Authors: Evan Lester, Felicia K. Ooi, Nadine Bakkar, Jacob Ayers, Amanda L. Woerman, Joshua Wheeler, Robert Bowser, George A. Carlson, Stanley B. Prusiner, Roy Parker
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease
Date: 02/2021
Authors: Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser
Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis
Date: 06/2020
Authors: J. Saul, E. Hutchins, R Reiman, M Saul, L W. Ostrow, B T. Harris, K Van Keuren-Jensen, R Bowser, Robert Bowser, N Bakkar, Nadine Bakkar
- English