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RAPID Consortium

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The RAPID (Registry for Adenomas of the Pituitary and related Disorders) Consortium is a multicenter surgical outcomes collaboration database founded at Barrow Neurological Institute and directed by our faculty to improve treatments for patients with pituitary tumors. We are studying Cushing’s disease, acromegaly, prolactinomas, and non-functioning pituitary adenomas. The RAPID consortium tracks elements important to studying pituitary surgery patient outcomes, which include patient medical history, surgery, pathology, follow-up, and remission status.

pituitary neurosurgeon andrew little discusses an mri scan with a patient

Mission

To serve the clinician-scientist through accelerating pituitary tumor research by:

  1. Developing a platform for multicenter clinical and translational research
  2. Promoting collegiality and scholarship
  3. Applying innovative solutions to the challenges of outcomes research

neuro-endocrinologist kevin yuen consults with a patient in an exam room

Awards

  1. Mizuho Minimally Invasive Brain Tumor Surgery Award, Danielle Wishart, 2024, CNS, Houston, Comparison of Outcomes Following Surgical Intervention for MRI-positive versus MRI-negative Cushing’s Disease: A Multi-Center Study.
  2. Fred Gentili Clinical Excellence Award, Cushing’s disease readmission after surgery. Mark Pacult, 2024, NASBS, Atlanta

Publications

Salcedo-Sifuentes, J.E., Mehta, S., Suryadevara, C.M. et al. Development and validation of clinical screening systems for Cushing disease in the United States. Pituitary 28, 108 (2025).10 October 2025. doi: 10.1007/s11102-025-01583-4.

Pacult MA, Karsy M, Evans JJ, Kim W, Pacione DR, Gardner PA, Fernandez-Miranda JC, Zada G, Rennert RC, Silverstein JM, Kim AH, Kshettry VR, Chicoine MR, Little AS. A Multicenter Study of Unplanned Hospital Readmissions after Transsphenoidal Surgery for Cushing’s Disease. J Neurol Surg B Skull Base. 2024 Aug 20. doi: 10.1055/s-0044-1789193.

Karsy M, Kshettry V, Gardner P, Chicoine M, Fernandez-Miranda JC, Evans JJ, Barkhoudarian G, Hardesty D, Kim W, Zada G, Crocker T, Torok I, Little A. The RAPID Consortium: A Platform for Clinical and Translational Pituitary Tumor Research. J Neurol Surg B Skull Base. 2022 Dec 30;85(1):1-8. doi: 10.1055/a-1978-9380. PMID: 38274483; PMCID: PMC10807961.

Findlay MC, Tenhoeve S, Alt J, Rennert RC, Couldwell WT, Evans J, Collopy S, Kim W, Delery W, Pacione D, Kim A, Silverstein JM, Chicoine MR, Gardner P, Rotman L, Yuen KCJ, Barkhoudarian G, Fernandez-Miranda J, Benjamin C, Kshettry VR, Zada G, Van Gompel J, Catalino MP, Little AS, Karsy M. Predictors of Durable Remission After Successful Surgery for Cushing Disease: Results From the Multicenter RAPID Registry. Neurosurgery. 2024 Oct 1;95(4):761-769. doi: 10.1227/neu.0000000000003042. Epub 2024 Jun 21. PMID: 39293794.

Findlay MC, Rennert RC, Lucke-Wold B, Couldwell WT, Evans JJ, Collopy S, Kim W, Delery W, Pacione DR, Kim AH, Silverstein JM, Kanga M, Chicoine MR, Gardner PA, Valappil B, Abdallah H, Sarris CE, Hendricks BK, Torok IE, Low TM, Crocker TA, Yuen KCJ, Vigo V, Fernandez-Miranda JC, Kshettry VR, Little AS, Karsy M. Impact of Frailty on Surgical Outcomes of Patients With Cushing Disease Using the Multicenter Registry of Adenomas of the Pituitary and Related Disorders Registry. Neurosurgery. 2024 Jul 10. doi: 10.1227/neu.0000000000003090. Epub ahead of print. PMID: 38985563.

Little AS, Karsy M, Evans JJ, Kim W, Pacione DR, Kim AH, Gardner PA, Hendricks BK, Sarris CE, Torok IE, Low TM, Crocker TA, Valappil B, Kanga M, Abdallah H, Collopy S, Fernandez-Miranda JC, Vigo V, Ljubimov VA, Zada G, Garrett NE 3rd, Delery W, Yuen KCJ, Rennert RC, Couldwell WT, Silverstein JM, Kshettry VR, Chicoine MR; RAPID Consortium. Multicenter Registry of Adenomas of the Pituitary and Related Disorders: Initial Description of Cushing Disease Cohort, Surgical Outcomes, and Surgeon Characteristics. Neurosurgery. 2024 Aug 1;95(2):372-379. doi: 10.1227/neu.0000000000002888. Epub 2024 Mar 5. PMID: 39008545.