Department of Neurology

Enroll HD is a longitudinal, observational, multinational study that will integrate two existing Huntington’s Disease registries, REGISTRY in Europe and COHORT in North America and Australia, while also expanding to include sites in Latin America and Asia. The goal is the build a large and...

This Phase 3, multi center, open-label study will assess the long-term safety of continuous infusion apomorphine in advanced Parkinson’s disease (PD) patients who are unable to achieve adequate control despite optimized noninvasive therapy. Further, this study will assess the clinical effectiveness of continuous infusion apomorphine...

This is a phase IIa, first in human, randomized, double-blind, multicenter study to evaluate the safety, tolerability and efficacy of DA-9805 at 45mg, 90mg versus placebo in subjects diagnosed with early Parkinson’s disease. Parkinson’s disease (PD) is recognized as one of the most common neurologic disorders, affecting...

The purpose of this program is to create a postmortem (after death) tissue bank of spinal cord, muscle, and brain tissue samples from both amyotrophic lateral sclerosis (ALS) patients and those without the disease (control subjects). Tissue donation provides an important and vital resource toward...

The purpose of this study is to determine whether magnetic resonance imaging (MRI) cytography (a type of noninvasive body scan) is useful in establishing disease severity in individuals with amyotrophic lateral sclerosis (ALS). MRI cytography will be compared to measures typically taken at clinic visits...

The Lysosomal Storage Disorders (LSD) Registry Program is a multicenter, international, observational program for people with certain rare diseases. It is designed to track the natural history and outcomes of patients. Currently, patients diagnosed with Pompe disease may participate in this registry program. No experimental...

FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun. It is unclear if, in the relapsing phase, there is an advantage of early aggressive therapy with respect to preventing long-term disability....

The overall goal of ADNI3 is to determine the relationships among the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer’s disease (AD), as the pathology evolves from normal aging through very mild symptoms, to mild cognitive impairment (MCI), to...

The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer’s disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals...

Preclinical models suggest that riluzole, the active metabolite of BHV-4157, may protect from AD-related pathology and cognitive dysfunction. Titrated dose of BHV-4157 to 280 mg, or placebo, taken orally once daily. Duration of treatment is 48 weeks. There is also a screening period of up...

This randomized, double-blind, placebo-controlled, parallel group study will evaluate the efficacy and safety of gantenerumab versus placebo in participants with early (prodromal to mild) AD. All participants must show evidence of beta-amyloid pathology. Eligible participants will be randomized 1:1 to receive either subcutaneous (SC) injection...

The primary objective of the placebo-controlled period is to evaluate the safety and tolerability of BIIB092 in participants with mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) or with mild AD. The secondary objectives of the placebo-controlled period are to evaluate the efficacy of...

To evaluate the safety and efficacy of IPX203 (carbidopa and levodopa) extended-release capsules (IPX203 ER CD-LD) in comparison to immediate release (IR) CD-LD in the treatment of CD-LD-experienced subjects with Parkinson’s disease (PD) who have motor fluctuations. This is a multicenter, randomized, double-blind, double-dummy, active-controlled,...

A randomized placebo-controlled trial to evaluate the safety and efficacy of three doses of study drug LY3154207 treated for 12 weeks in participants with mild-to-moderate dementia associated with LBD (PDD or DLB).

The purpose of this study is to compare the efficacy of BHV-3241 versus placebo in subjects with multiple system atrophy.

The purpose of this study is to compare the efficacy of Troriluzole (200mg once daily) versus placebo after 48 weeks of treatment in subjects with spinocerebellar ataxia (SCA).

This is a multicenter, randomized, double-blind, placebo-controlled, three-arm parallel group study to evaluate the efficacy, safety, and pharmacokinetics (PK) of pridopidine versus placebo for the treatment of Levodopa-induced dyskinesia (LID) in patients with Parkinson’s disease.

A Phase 3 study to evaluate efficacy, safety, and tolerability of ampreloxetine (TD-9855) in subjects with primary autonomic failures (MSA, PD, or PAF) and snOH with up to 4 weeks of treatment. A Phase 3, randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate efficacy, safety,...

The purpose of the Parkinson’s disease Registry is to develop a national and international database of persons with Parkinson’s disease (PD). The Registry will be used to facilitate the development of new therapies and healthcare services to improve the quality of life for people with...

This is an observational, multicenter, longitudinal cohort study to characterize adults with Down syndrome ages 25 years and above enrolled at specialized care centers. The aim is to assess changes in cognition, behavior, function, and health over approximately 24 months. Blood will be collected for...

The purpose of this study is to identify biomarkers to serve as quantifiable measures of Edaravone effects in ALS in those who are initiating clinically prescribed Edaravone treatment for the first time or within one month of consenting. Participants in the study will be followed...

The purpose of this study is to assess the clinical efficacy, safety and tolerability of Rozanolixizumab, which is a type of antibody that helps breakdown harmful auto-antibodies in generalized myasthenia gravis patients. Rozanolixizumab will be administered through a 30-minute subcutaneous infusion (i.e. a small needle...

The purpose of this study is to evaluate the efficacy, safety, and tolerability of HYQVIA/HyQvia as a maintenance therapy to prevent relapse and for the treatment of CIDP. Subjects must be on a stable dosing regimen of IVIG therapy for at least 12 weeks prior...

The primary efficacy objective of this study is to test the hypothesis that DBS-f stimulation (ON) will slow cognitive and functional progression of AD, as compared to no stimulation (OFF), by measuring baseline (pre-implantation) to 12-month change in the integrated Alzheimer’s disease rating scale (iADRS).

Huntington’s disease (HD) is a rare, inherited and progressive neurodegenerative disorder for which hallmark symptoms include movement disorders, loss of cognitive faculties and psychiatric disturbances. With the progression of the disease, patients require increasing level of medical care, caregiver support, and long-term care, which lead...

This study aims to determine the most effective dose of light therapy to improve sleep in people with Parkinson’s Disease. Four groups of participants will receive bright-white or dim-red light therapy at different times throughout the day. This is a 16-week, randomized, phase II, parallel-group,...

Diagnosing Parkinson’s disease (PD) depends on the clinical history of the patient and the patient’s response to specific treatments such as levodopa. Unfortunately, a definitive diagnosis of PD is still limited to post-mortem evaluation of brain tissues. Furthermore, diagnosis of idiopathic PD is even more...

Parkinson’s disease (PD) is a neurological condition, which affects the brain. PD gets worse over time, but how quickly it progresses varies a lot from person to person. Some symptoms of PD are tremors, stiffness, and slowness of movement. This study measures the efficacy, safety,...

Patient Experiences with Parkinson’s Disease Treatments: A Mixed-Methods Study.

Registry for the advancement of DBS in Parkinson’s disease.

Blinded comparison of different alpha-synuclein seeding assays as cutaneous biomarkers of Lewy body dementias. Beach-NIH/R01 (NS118669-01). Purpose The purpose of this research is to determine the ability of skin biopsy analysis to predict a diagnosis of Lewy body dementia, and to determine whether the results...

The purpose of this study is to evaluate how offering Clinical Laboratory Improvement Amendments (CLIA) certified genetic testing for Parkinson’s Disease (PD) genes to people with Parkinson’s Disease impacts clinical care and potential enrollment in clinical trials. This multi-center study will assess the impact and...

PPMI 2.0 is a broad program, expanding the goals of the original PPMI study (NCT01141023), that includes this PPMI 2.0 Clinical protocol, as well as the PPMI 2.0 Remote, PPMI 2.0 Digital Applications and PPMI 2.0 Online protocols. All participants in PPMI 2.0 will be...

The purpose of this platform trial is to evaluate the efficacy of multiple study drugs at once, as compared with placebo, on ALS disease progression. New treatment regimens (drugs) will be added as they become available within the trial, meaning that multiple drug treatment regimens...

Full Study Name: A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson’s Disease (ENLITE PD – NN110) Description: The ENLITE PD – NN110 study is a 16-week, phase II, multi-center, randomized, parallel-group, dose-selection trial of light therapy in participants with Parkinson’s Disease...

Alzheimer’s disease (AD) is a fatal neurodegenerative disease that is manifested by progressive cognitive deficits including memory loss followed by loss of independent function as well as neuropsychiatric symptoms such as apathy, depression, anxiety, agitation and psychosis. JNJ-63733657 is a humanized monoclonal anti-tau antibody which...

This is a phase 3 double blind, placebo controlled study evaluating the efficacy and safety of AL001 administered intravenously in participants at risk for or with frontotemporal dementia due to heterozygous mutations in the progranulin gene. Full Name: A Phase 3 Study to Evaluate Efficacy...

The primary objective is to evaluate the long-term safety and tolerability of aducanumab after a wash-out period imposed by discontinuation of feeder studies in participants who had previously received aducanumab (i.e. previously treated participants) or who had previously received placebo (i.e. treatment-naïve participants). Full Name:...

A Phase 3, Multi-center, Randomized, Double-blind, Parallel-group, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Sodium Oligomannate (GV-971) in Treatment of Mild to Moderate Alzheimer’s Disease (GREEN MEMORY: GREen Valley 971 EvaluatioN Memory) The purpose of this study is to evaluate the safety,...

Barrow Neurological Institute Database for Spontaneous Intracranial Hypotension The purpose of this study is to create a database of clinical features and imaging data from patients seen at Barrow Neurological Institute (BNI) with a diagnosis of spontaneous intracranial hypotension (SIH). The database will help determine...

Quantitative Analysis of Thecal Sac Volume and Morphology as a Diagnostic Tool in Intracranial Hypotension The purpose of this study is to test the effectiveness of a new imaging tool to increase the confidence in diagnosis of spontaneous intracranial hypotension (SIH). SIH is a condition...

This research is being done to figure out whether treatment for sleep apnea, in people who have had a stroke or TIA, improves recovery from stroke, and helps prevent future stroke, heart problems, and death. The intervention being tested is called continuous positive airway pressure...

StATins Use in intRacereberal hemorrhage patieNts (SATURN) This research is being done to find out if it is better to continue or discontinue statin drugs in people who had a brain hemorrhage while taking a statin drug. Statin drugs help prevent heart disease and ischemic...

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction This is a Phase 3 study, which means that BIIB093 (study drug) has already been investigated in previous clinical research studies...

Phase 2A Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of Intravenous ANX005 in Subjects with Amyotrophic Lateral Sclerosis The purpose of this study is to evaluate the safety and tolerability of ANX005, which is a monoclonal antibody that is being developed to treat ALS in adult...

Efficacy and Safety Study of Oral Edaravone Administered to Subjects with ALS The purpose of this trial is to evaluate and compare the efficacy, safety, tolerability, and changes in nerve conduction tests of 2 different dosing regimens of oral edaravone (study drug) in participants with...

A Phase 3, Multi-Center, Double-blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Reldesemtiv in Patients with ALS The purpose of this trial is to evaluate the effect of reldesemtiv (study drug) v. placebo on ALSFRS-R, FVC, quality of life scales, muscle and...

A Phase 2a Open-Label, Multi-Center Study to Evaluate the Safety and Tolerability of Multiple Doses of AT-1501 in Adults with ALS The purpose of this trial is to determine the safety and tolerability of multiple doses of AT-1501 (study drug) in participants with ALS. Additionally,...

Long-Term, Observational, Registry of Patients with Generalized Myasthenia Gravis Who Have Received Treatment With Complement C5 Inhibition Therapies This is a registry study that focuses on patients with Myasthenia Gravis (MG) who have used complement inhibitors. Soliris is an example of this type of medication....

A Multi-Center, Longitudinal Study of the Natural History of Subjects with Limb Girdle Muscular Dystrophy (LGMD) Type 2E (LGMD2E/R4), Type 2D (LGMD2D/R3), and Type 2C (LGMD2C/R5) The purpose of this study is to learn about the natural progression of LGMD sarcoglycanopathies (types 2E, 2D, and...

Reliability Studies of Multipoint Incremental MUNE in the Lower Extremities The purpose of this study is to evaluate the application of multipoint incremental motor unit number estimate (MIMUNE), an electromyography (EMG) technique, in 2 distinct muscles of the leg called the extensor digitorum brevis and...

Electrical Impedance Myography Technology for Quantitative, At-home Muscle Assessment in Amyotrophic Lateral Sclerosis (EIM-At-Home) This research is being performed to evaluate the reliability and ease of use of the improved mScan™ EIM (electrical impedance myography) device as a potential biomarker for ALS for patients to...

Lysosomal Storage Disorders (LSD) Registry Program – Pompe Registry The LSD Registry program is a multi-center, international, observational program for patients with certain rare diseases designed to track the natural history and outcomes of patients. Currently, patients diagnosed with Pompe disease may participate in this...

Phase 1/2, Dose-escalation Study to Evaluate the Safety, Tolerability and Efficacy of a Single Intravenous Infusion of SPK-3006 in Adults with Late-onset Pompe Disease The purpose of this study is to evaluate the safety, tolerability, and efficacy of SPK-3006, which is a novel investigational gene...

Target ALS Biomarker Study: Longitudinal Biofluids, Clinical Measures, and At-Home Measures The purpose of this study is to generate a biorepository of longitudinal blood (plasma and serum), cerebral spinal fluid (CSF), and urine linked to genetics and clinical information that are then made available to...

What is the purpose of the study? The purpose of this study is to see whether at-home measurements are dependable and can help with tracking disease progression.  What procedures will I participate in if I choose to enroll in the study? You will be required...

Interventional, randomized, double-blind, parallel-group, placebo-controlled delayed-start study to evaluate the efficacy and safety of eptinezumab in patients with episodic cluster headache. The purpose of this study is to evaluate the efficacy of eptinezumab inpatients with cluster headache. We anticipate that approximately 304 patients will participate...

What is the FASTEST Trial?  Barrow Neurological Institute is conducting a research study of the emergency treatment of patients with bleeding in the brain, also called intracerebral hemorrhage. Barrow Neurological Institute has joined a partnership of over 100 other hospitals and mobile stroke units across North...

DISCOVERY is a prospective, multicenter, observational, nested-cohort study with the overarching objectives to identify specific stroke subtypes associated with risk of PSCID in diverse US populations and elucidate mechanisms of PSCID through systematic assessment of the effect of acute stroke and its interaction with antecedent...

MultiStem is an allogeneic, regenerative medicine advanced therapy indicated for treatment of acute ischemic stroke within 36 hours after symptom onset. The primary objective of this study is to evaluate the efficacy of MultiStem on functional outcome in subjects with ischemic stroke. This is a...

This is a randomized clinical trial to determine the efficacy and safety of andexanet compared to usual care in patients presenting with acute intracerebral hemorrhage within 6 hours of symptom onset (from the baseline scan) and within 15 hours of taking an oral FXa inhibitor...

This is a 12-week, double-blind, placebo-controlled, randomized, parallel-group, multicenter study of the safety and efficacy of JZP385 in the treatment of adult participants with moderate to severe essential tremor. Purpose The purpose of this study is to find out whether an investigational drug called JZP385...

This is a Phase 2a multi-center, randomized, double-blind, placebo-controlled parallel-group, 4-arm study with an open-label treatment phase in patients with progressive supranuclear palsy (PSP). This study includes a 6-week screening period, a 24-week double-blind treatment period, a 24-week open label treatment period, and a follow-up...

This is a multicenter, randomized, double-blind, placebo-controlled study that will evaluate the efficacy and safety of intravenous (IV) prasinezumab versus placebo in participants with early Parkinson’s disease (PD) who are on stable symptomatic PD medication. Purpose The purpose of this study is to compare the...

Progressive gait dysfunction is one of the main motor symptoms in people with Parkinson’s disease (PD). It is generally expressed as reduced step length and gait speed, and as increased variability in step time and length. People with Parkinson’s disease also exhibit stooped posture, which...

Purpose The study will help us learn more about the effects of Parkinson’s disease and/or progressive supranuclear palsy and medication on aspects of vision. Who Can Participate Patients with Parkinson’s disease or progressive supranuclear palsy that are doing on-off testing with their physician at Barrow...

Purpose This study will test a new deep brain stimulation (DBS) site that is expected to better address these features of Parkinson’s disease. Who Can Participate Parkinson’s disease patients that are discussing deep brain stimulation therapy with their physician and have difficulties with gait, balance,...

Purpose The study will help us obtain more exact data about Parkinson’s disease motor symptoms. Who Can Participate People with a Parkinson’s disease diagnosis can participate in this study. Visits The study will consist of a single visit of less than 30 minutes that can...

The purpose of this trial is to develop a new magnetic resonance imaging (MRI) method to accurately diagnose, predict, track progression, and monitor the response to treatment in Parkinson’s disease. Purpose This study is being done in hopes of developing new MRI methods to accurately...

Development of a central repository for Parkinson’s disease-related genomic data for future research. Purpose This study will obtain genetic samples to investigate the genetic link to Parkinson’s disease. Patients can receive their genetic results if they wish. Who Can Participate Male and female patients over...

Prospective observational study of 3 month response to external combined occipital and trigeminal neurostimulation (eCOT-NS). The purpose of this study is to compare the responses and treatment adherence of the standard of care use of the FDA approved external combined occipital and trigeminal neurostimulation (eCOT-NS) device...

A phase 1, study of the safety and tolerability of single doses of ANK-700 in patients with relapsing-remitting Multiple Sclerosis. Purpose The purpose of this study is to look at how safe it is to take single or multiple doses of the study drug in...

A phase-2B, double-blind, randomized controlled trial to evaluate the activity and safety of inebilizumab in anti-NMDA receptor encephalitis and assess markers of disease. Purpose There are currently no medicinal products approved for the treatment of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, a rare disease. NMDAR encephalitis is...

An 18-month, open-label, multi-center phase IV study to assess the effect of ofatumumab 20mg SC monthly in treatment naïve, very early relapsing remitting multiple sclerosis. Purpose The purpose of this study is to complement the ofatumumab clinical development pivotal trials by demonstrating clinical and MRI...

In this project, we propose to validate objective measures of sideline and post-injury assessment of postural stability, near point of convergence, and pupillometry in NFL athletes suspected of sustaining a concussion. Both balance and eye movements are already included in the standard of care for...

Purpose This purpose of this study is to help determine if UCB0599 (an oral therapy targeting alpha synuclein) can slow the progression/worsening of Parkinson’s disease. Due to the way the study drug works in the brain, it is not expected to provide immediate relief to...

Purpose The purpose of this study is to learn more about how aerobic exercise affects symptoms of Parkinson’s disease and quality of life in people that have deep brain stimulation. Who can participate Visits Study is 16 weeks with 8 in clinic visits. Principle Investigator

Purpose The purpose of this study is to learn if deep brain stimulation (DBS) in the posterior subthalamic area (PSA) can be used with the usual area of stimulation, called the VIM (ventral intermediate nucleus) to control a person’s Essential Tremor (ET). Who can participate...

A pilot study examining the effects of pre-treatment with Korlym before performing bilateral inferior petrosal sinus sampling in patients with Cushing syndrome. Purpose This study will assess if by increasing ACTH and cortisol levels by virtue of antagonizing the glucocorticoid receptors with Korlym which will...

A phase 3, double-blind, placebo-controlled, randomized-withdrawal study of the efficacy and safety of relacorilant. Purpose This study will evaluate the efficacy and safety of GR antagonism by relacorilant, with an emphasis on two robust and validated endpoints, blood glucose control and blood pressure (BP) control,...

A multicenter, randomized, parallel-arm, placebo-controlled (double-blind) and active controlled (open-label) trial to compare the efficacy and safety of once-weekly lonapegsomatropin with placebo and a daily somatropin product in adults with growth hormone deficiency. Purpose Primary objective is to evaluate the efficacy of once-weekly lonapegsomatropin compared...

A multicenter, open-label, extension trial to investigate long term efficacy and safety of lonapegsomatropin in adults with growth hormone deficiency. Purpose This is a phase 3 open-label multicenter extension trial designed to evaluate the long-term safety and efficacy of lonapegsomatropin administered once-weekly. The trial participants...

Purpose The purpose of this study is to evaluate the safety and efficacy of botox for the treatment of upper limb essential tremor.  Who can participate? Patients with diagnosed essential tremor >3 years Essential tremor requirements (all in dominant limb): Principle Investigator

AbbVie / Episodic Migraine: Phase 3 Study of BOTOX (Botulinum Toxin Type A) for the Prevention of Migraine in Subjects with Episodic Migraine Purpose The purpose of this study is to see if the study drug, BOTOX®, is safe and helps prevent episodic migraines in...

A Phase 3 Multicenter 24-Week Open-Label Study to Evaluate the Safety, Tolerability, and Efficacy of Atogepant When Added to OnabotulinumtoxinA (BOTOX) for the Preventive Treatment of Chronic Migraine Purpose The purpose of this study is to see if the study drug, Atogepant, is safe and...

Purpose This is a prospective, randomized, double-blinded study that will be performed at Barrow Neurological Institute in the Jan and Tom Lewis Migraine Treatment Program. This study will enroll patients who are naïve to nerve blocks who are planning on receiving nerve blocks as their...